Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate, and adaptive immunity. We have employed two orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins down-regulated by viral factors expres...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2022-02, Vol.119 (6), p.1-7 |
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| creator | Nightingale, Katie Potts, Martin Hunter, Leah M. Fielding, Ceri A. Zerbe, Cassie M. Fletcher-Etherington, Alice Nobre, Luis Wang, Eddie C. Y. Strang, Blair L. Houghton, Jack W. Antrobus, Robin Suarez, Nicolas M. Nichols, Jenna Davison, Andrew J. Stanton, Richard J. Weekes, Michael P. |
| description | Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate, and adaptive immunity. We have employed two orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins down-regulated by viral factors expressed during the latest phases of viral infection. This approach revealed that the HIV-1 restriction factor Schlafen-11 (SLFN11) was degraded by the poorly characterized, late-expressed HCMV protein RL1, via recruitment of the Cullin4-RING E3 Ubiquitin Ligase (CRL4) complex. SLFN11 potently restricted HCMV infection, inhibiting the formation and spread of viral plaques. Overall, we show that a restriction factor previously thought only to inhibit RNA viruses additionally restricts HCMV. We define the mechanism of viral antagonism and also describe an important resource for revealing additional molecules of importance in antiviral innate immunity and viral immune evasion. |
| doi_str_mv | 10.1073/pnas.2108173119 |
| format | Article |
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Y. ; Strang, Blair L. ; Houghton, Jack W. ; Antrobus, Robin ; Suarez, Nicolas M. ; Nichols, Jenna ; Davison, Andrew J. ; Stanton, Richard J. ; Weekes, Michael P.</creator><creatorcontrib>Nightingale, Katie ; Potts, Martin ; Hunter, Leah M. ; Fielding, Ceri A. ; Zerbe, Cassie M. ; Fletcher-Etherington, Alice ; Nobre, Luis ; Wang, Eddie C. Y. ; Strang, Blair L. ; Houghton, Jack W. ; Antrobus, Robin ; Suarez, Nicolas M. ; Nichols, Jenna ; Davison, Andrew J. ; Stanton, Richard J. ; Weekes, Michael P.</creatorcontrib><description>Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate, and adaptive immunity. We have employed two orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins down-regulated by viral factors expressed during the latest phases of viral infection. This approach revealed that the HIV-1 restriction factor Schlafen-11 (SLFN11) was degraded by the poorly characterized, late-expressed HCMV protein RL1, via recruitment of the Cullin4-RING E3 Ubiquitin Ligase (CRL4) complex. SLFN11 potently restricted HCMV infection, inhibiting the formation and spread of viral plaques. Overall, we show that a restriction factor previously thought only to inhibit RNA viruses additionally restricts HCMV. We define the mechanism of viral antagonism and also describe an important resource for revealing additional molecules of importance in antiviral innate immunity and viral immune evasion.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.2108173119</identifier><identifier>PMID: 35105802</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adaptive immunity ; Biological Sciences ; Cytomegalovirus ; Cytomegalovirus - genetics ; Cytomegalovirus - immunology ; Cytomegalovirus Infections - genetics ; Cytomegalovirus Infections - immunology ; HIV ; Human immunodeficiency virus ; Humans ; Immune Evasion ; Immunity ; Innate immunity ; Nuclear Proteins - genetics ; Nuclear Proteins - immunology ; Plaques ; Proteins ; Proteolysis ; Proteomics ; Recruitment ; RNA viruses ; Ubiquitin ; Ubiquitin-protein ligase ; Ubiquitin-Protein Ligase Complexes - genetics ; Ubiquitin-Protein Ligase Complexes - immunology ; Viral Envelope Proteins - genetics ; Viral Envelope Proteins - immunology ; Viral infections</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (6), p.1-7</ispartof><rights>Copyright © 2022 the Author(s). Published by PNAS.</rights><rights>Copyright National Academy of Sciences Feb 8, 2022</rights><rights>Copyright © 2022 the Author(s). 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| subjects | Adaptive immunity Biological Sciences Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus - immunology Cytomegalovirus Infections - genetics Cytomegalovirus Infections - immunology HIV Human immunodeficiency virus Humans Immune Evasion Immunity Innate immunity Nuclear Proteins - genetics Nuclear Proteins - immunology Plaques Proteins Proteolysis Proteomics Recruitment RNA viruses Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligase Complexes - genetics Ubiquitin-Protein Ligase Complexes - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral infections |
| title | Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex |
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