Cellular-Resolution Imaging of Bystander Payload Tissue Penetration from Antibody-Drug Conjugates

After several notable clinical failures in early generations, antibody-drug conjugates (ADC) have made significant gains with seven new FDA approvals within the last 3 years. These successes have been driven by a shift towards mechanistically informed ADC design, where the payload, linker, drug-to-a...

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Veröffentlicht in:	Molecular cancer therapeutics 2022-02, Vol.21 (2), p.310-321
Hauptverfasser:	Khera, Eshita, Dong, Shujun, Huang, Haolong, de Bever, Laureen, van Delft, Floris L, Thurber, Greg M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Immunoconjugates - chemistry Immunoconjugates - pharmacology
Online-Zugang:	Volltext
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