Prenatal Poly I:C Challenge Affects Behaviors and Neurotransmission via Elevated Neuroinflammation Responses in Female Juvenile Rats

Abstract Background Exposure to polyriboinosinic-polyribocytidylic acid (Poly I:C) in pregnant rats has been reported to cause schizophrenia-like behaviors and abnormal neurotransmissions in adult, particularly male, offspring. However, what is less well understood are the effects of maternal Poly I...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2022-02, Vol.25 (2), p.160-171
Hauptverfasser:	Su, Yueqing, Lian, Jiamei, Hodgson, James, Zhang, Wenchang, Deng, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal Brain - drug effects Child psychopathology Cognition - drug effects Complications and side effects Disease Models, Animal Female Health aspects Hippocampus - drug effects Memory, Short-Term - drug effects Neural transmission Neuroinflammatory Diseases - metabolism Nucleoside analogs Physiological aspects Poly I-C - pharmacology Prefrontal Cortex - metabolism Pregnancy Prenatal Exposure Delayed Effects - metabolism Prenatal influences Prepulse Inhibition - drug effects Psychological aspects Rats Receptors, Dopamine D2 - metabolism Regular s Risk factors Schizophrenia - metabolism Synaptic Transmission - drug effects Teenage girls
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