Evaluation of the Safety, Tolerability, and Pharmacokinetic Profiles of TP0473292 (TS-161), A Prodrug of a Novel Orthosteric mGlu2/3 Receptor Antagonist TP0178894, in Healthy Subjects and Its Antidepressant-Like Effects in Rodents

Abstract Background TP0473292 (the active ingredient of TS-161) is a prodrug of a novel metabotropic glutamate (mGlu) 2/3 receptor antagonist being developed for the treatment of patients with depression. This study evaluated the safety, tolerability, and pharmacokinetics of orally administered TS-1...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2022-02, Vol.25 (2), p.106-117
Hauptverfasser:	Watanabe, Mai, Marcy, Brian, Hiroki, Ayano, Watase, Hirotaka, Kinoshita, Kohnosuke, Iijima, Michihiko, Marumo, Toshiyuki, Zarate, Carlos A, Chaki, Shigeyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult AMPA receptors Animals Antidepressants Antidepressive Agents - therapeutic use Area Under Curve Depression - drug therapy Dose-Response Relationship, Drug Double-Blind Method Female Health aspects Humans Male Middle Aged Physiological aspects Prodrugs Receptors, Metabotropic Glutamate - administration & dosage Regular s Rodentia Testing Young Adult
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