Enhanced nuclear localization of YAP1‐2 contributes to EGF‐induced EMT in NSCLC

YAP1, a key mediator of the Hippo pathway, plays an important role in tumorigenesis. Alternative splicing of human YAP1 mRNA results in two major isoforms: YAP1‐1, which contains a single WW domain, and YAP1‐2, which contains two WW domains, respectively. We here investigated the functions and the u...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2022-02, Vol.26 (4), p.1013-1023
Hauptverfasser:	Guo, Qiang, Quan, Mei‐Yu, Xu, Le, Cai, Yaxin, Cai, Jue‐Ting, Li, Xue, Feng, Guifeng, Chen, Aiping, Yang, Weiwei, Dhlamini, Qhaweni, Jiang, Tian‐Fang, Shen, Chengguo, Chen, Chengshui, Zhang, Jin‐San
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism AKT protein AKT signalling Alternative splicing Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Cell adhesion & migration Cell culture Cell Line, Tumor Cell migration EGF Epidermal growth factor Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology Epithelial-Mesenchymal Transition - genetics epithelial‐mesenchymal transition Humans Isoforms Kinases Localization Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Mesenchyme Metastasis mRNA Mutation Non-small cell lung carcinoma NSCLC Original Phenotypes Proteins Small cell lung carcinoma Software Statistical analysis Transcription Factors - genetics Transcription Factors - metabolism Tumor cell lines Tumorigenesis YAP-Signaling Proteins YAP1 isoforms Yes-associated protein
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