PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids

Microglia are the resident immune cells of the central nervous system (CNS). They govern the immunogenicity of the retina, which is considered to be part of the CNS; however, it is not known how microglia develop in the eye. Here, we studied human-induced pluripotent stem cells (hiPSCs) that had bee...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Stem cell reports 2022-02, Vol.17 (2), p.221-230
Hauptverfasser:	Shiraki, Nobuhiko, Maruyama, Kazuichi, Hayashi, Ryuhei, Oguchi, Akiko, Murakawa, Yasuhiro, Katayama, Tomohiko, Takigawa, Toru, Sakimoto, Susumu, Quantock, Andrew J., Tsujikawa, Motokazu, Nishida, Kohji
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokines - pharmacology development ESC Eye - cytology Eye - growth & development Gene Expression Regulation - drug effects Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism iPSC Lipopolysaccharides - pharmacology microglia Microglia - metabolism neuronal immunity ocular organoid Organoids - cytology Organoids - metabolism PAX6 Transcription Factor - genetics PAX6 Transcription Factor - metabolism Phagocytosis pluripotent stem cell
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!