Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform

Virus-like particles (VLPs) are highly suited platforms for protein-based vaccines. In the present work, we adapted a previously designed non-infectious adenovirus-inspired 60-mer dodecahedric VLP (ADDomer) to display a multimeric array of large antigens through a SpyTag/SpyCatcher system. To valida...

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Veröffentlicht in:	Molecular therapy 2022-05, Vol.30 (5), p.1913-1925
Hauptverfasser:	Chevillard, Christopher, Amen, Axelle, Besson, Solène, Hannani, Dalil, Bally, Isabelle, Dettling, Valentin, Gout, Evelyne, Moreau, Christophe J., Buisson, Marlyse, Gallet, Salomé, Fenel, Daphna, Vassal-Stermann, Emilie, Schoehn, Guy, Poignard, Pascal, Dagher, Marie-Claire, Fender, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenoviridae - genetics Adenovirus Animals Antibodies, Neutralizing Antibodies, Viral Antigen display Biochemistry, Molecular Biology COVID-19 COVID-19 - prevention & control COVID-19 Vaccines Cryoelectron Microscopy Humans Life Sciences Mice Neutralizing antibodies Original Receptor-binding domain SARS-CoV-2 Structural Biology Vaccination Vaccine platform Virus-like particle
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