Deletion of the H240R Gene of African Swine Fever Virus Decreases Infectious Progeny Virus Production Due to Aberrant Virion Morphogenesis and Enhances Inflammatory Cytokine Expression in Porcine Macrophages

African swine fever virus (ASFV) is a complex nucleocytoplasmic large DNA virus that causes African swine fever, a lethal hemorrhagic disease that currently threatens the pig industry. Recent studies have identified the viral structural proteins of infectious ASFV particles. However, the functional...

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Veröffentlicht in:	Journal of virology 2022-02, Vol.96 (3), p.e0166721-e0166721
Hauptverfasser:	Zhou, Pingping, Li, Lian-Feng, Zhang, Kehui, Wang, Bing, Tang, Lijie, Li, Miao, Wang, Tao, Sun, Yuan, Li, Su, Qiu, Hua-Ji
Format:	Artikel
Sprache:	eng
Schlagworte:	African Swine Fever - genetics African Swine Fever - metabolism African Swine Fever - pathology African Swine Fever Virus - physiology African Swine Fever Virus - ultrastructure Amino Acid Sequence Animals Capsid Proteins - chemistry Capsid Proteins - genetics Capsid Proteins - metabolism Cytokines - genetics Cytokines - metabolism Disease Susceptibility - immunology Gene Expression Profiling Gene Expression Regulation, Viral Genome and Regulation of Viral Gene Expression Genome Replication and Regulation of Viral Gene Expression Genome, Viral Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Macrophages - immunology Macrophages - metabolism Sequence Deletion Swine Veterinary Microbiology Virion - ultrastructure Virus Internalization Virus Replication
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