Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies
Diabetes is one of the most socially challenging health concerns. Even though islet transplantation has shown promise for insulin-dependent diabetes, there is still no effective method for curing diabetes due to the severe shortage of transplantable donors. In recent years, organoid technology has a...
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| Veröffentlicht in: | Theranostics 2022-01, Vol.12 (4), p.1537-1556 |
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| creator | Jiang, Lai Shen, Yiru Liu, Yajing Zhang, Lei Jiang, Wei |
| description | Diabetes is one of the most socially challenging health concerns. Even though islet transplantation has shown promise for insulin-dependent diabetes, there is still no effective method for curing diabetes due to the severe shortage of transplantable donors. In recent years, organoid technology has attracted lots of attention as organoid can mirror the human organ
to the maximum extent
thus bridging the gap between cellular- and tissue/organ-level biological models. Concurrently, human pancreatic islet organoids are expected to be a considerable source of islet transplantation. To construct human islet-like organoids, the seeding cells, biomaterials and three-dimensional structure are three key elements. Herein, this review summarizes current progresses about the cell origins, biomaterials and advanced technology being applied to make human islet organoids, and discusses the advantages, shortcomings, and future challenges of them as well. We hope this review can offer a cross-disciplinary perspective to build human islet organoids and provide insights for tissue engineering and regenerative medicine. |
| doi_str_mv | 10.7150/thno.66670 |
| format | Article |
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to the maximum extent
thus bridging the gap between cellular- and tissue/organ-level biological models. Concurrently, human pancreatic islet organoids are expected to be a considerable source of islet transplantation. To construct human islet-like organoids, the seeding cells, biomaterials and three-dimensional structure are three key elements. Herein, this review summarizes current progresses about the cell origins, biomaterials and advanced technology being applied to make human islet organoids, and discusses the advantages, shortcomings, and future challenges of them as well. We hope this review can offer a cross-disciplinary perspective to build human islet organoids and provide insights for tissue engineering and regenerative medicine.</description><identifier>ISSN: 1838-7640</identifier><identifier>EISSN: 1838-7640</identifier><identifier>DOI: 10.7150/thno.66670</identifier><identifier>PMID: 35198056</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Biocompatible Materials ; Biomedical materials ; Collagen ; Diabetes ; Glucose ; Humans ; Hydrogels ; Hyperglycemia ; Insulin ; Islets of Langerhans ; Islets of Langerhans Transplantation ; Organoids ; Pancreas ; Review ; Technology ; Tissue engineering</subject><ispartof>Theranostics, 2022-01, Vol.12 (4), p.1537-1556</ispartof><rights>The author(s).</rights><rights>2022. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-1203a868959992ee45ab43ee3a7e67aa7120534d94e8c4efe353251a9894e7af3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825586/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825586/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35198056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Lai</creatorcontrib><creatorcontrib>Shen, Yiru</creatorcontrib><creatorcontrib>Liu, Yajing</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Jiang, Wei</creatorcontrib><title>Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies</title><title>Theranostics</title><addtitle>Theranostics</addtitle><description>Diabetes is one of the most socially challenging health concerns. Even though islet transplantation has shown promise for insulin-dependent diabetes, there is still no effective method for curing diabetes due to the severe shortage of transplantable donors. In recent years, organoid technology has attracted lots of attention as organoid can mirror the human organ
to the maximum extent
thus bridging the gap between cellular- and tissue/organ-level biological models. Concurrently, human pancreatic islet organoids are expected to be a considerable source of islet transplantation. To construct human islet-like organoids, the seeding cells, biomaterials and three-dimensional structure are three key elements. Herein, this review summarizes current progresses about the cell origins, biomaterials and advanced technology being applied to make human islet organoids, and discusses the advantages, shortcomings, and future challenges of them as well. We hope this review can offer a cross-disciplinary perspective to build human islet organoids and provide insights for tissue engineering and regenerative medicine.</description><subject>Biocompatible Materials</subject><subject>Biomedical materials</subject><subject>Collagen</subject><subject>Diabetes</subject><subject>Glucose</subject><subject>Humans</subject><subject>Hydrogels</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Islets of Langerhans</subject><subject>Islets of Langerhans Transplantation</subject><subject>Organoids</subject><subject>Pancreas</subject><subject>Review</subject><subject>Technology</subject><subject>Tissue engineering</subject><issn>1838-7640</issn><issn>1838-7640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpd0V1rFTEQBuAgii21N_4ACXgj4tZk8-1FQYpfUNELvQ5zdufsSd1NjklW9N-bY2up5iZh8jDM8BLymLMzwxV7WXcxnWmtDbtHjrkVtjNasvt33kfktJQr1o5kvePuITkSijvLlD4mPz_CtxAnulsXiHQPccgINQw0lBkrTXmCmMJYXtHPOU0ZS8FCU6R1h3TAeW4iTCGWF3QT0gIVc4C5UIhjIxmxG8OCsYQUYaYVhzbtnKaA5RF5sG0ST2_uE_L17ZsvF--7y0_vPly8vuwGyXTteM8EWG2dcs71iFLBRgpEAQa1ATANKCFHJ9EOErcolOgVB2dbxcBWnJDz6777dbPgOGCsGWa_z2GB_MsnCP7fnxh2fko_vLW9Ula3Bs9uGuT0fcVS_RLKYXWImNbiey16y4x1ptGn_9GrtOa2eVNGM6sllwf1_FoNOZWScXs7DGf-kKk_ZOr_ZNrwk7vj39K_CYrflwefXQ</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Jiang, Lai</creator><creator>Shen, Yiru</creator><creator>Liu, Yajing</creator><creator>Zhang, Lei</creator><creator>Jiang, Wei</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220101</creationdate><title>Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies</title><author>Jiang, Lai ; Shen, Yiru ; Liu, Yajing ; Zhang, Lei ; Jiang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-1203a868959992ee45ab43ee3a7e67aa7120534d94e8c4efe353251a9894e7af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biocompatible Materials</topic><topic>Biomedical materials</topic><topic>Collagen</topic><topic>Diabetes</topic><topic>Glucose</topic><topic>Humans</topic><topic>Hydrogels</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Islets of Langerhans</topic><topic>Islets of Langerhans Transplantation</topic><topic>Organoids</topic><topic>Pancreas</topic><topic>Review</topic><topic>Technology</topic><topic>Tissue engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Lai</creatorcontrib><creatorcontrib>Shen, Yiru</creatorcontrib><creatorcontrib>Liu, Yajing</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Jiang, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Theranostics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Lai</au><au>Shen, Yiru</au><au>Liu, Yajing</au><au>Zhang, Lei</au><au>Jiang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies</atitle><jtitle>Theranostics</jtitle><addtitle>Theranostics</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>12</volume><issue>4</issue><spage>1537</spage><epage>1556</epage><pages>1537-1556</pages><issn>1838-7640</issn><eissn>1838-7640</eissn><abstract>Diabetes is one of the most socially challenging health concerns. Even though islet transplantation has shown promise for insulin-dependent diabetes, there is still no effective method for curing diabetes due to the severe shortage of transplantable donors. In recent years, organoid technology has attracted lots of attention as organoid can mirror the human organ
to the maximum extent
thus bridging the gap between cellular- and tissue/organ-level biological models. Concurrently, human pancreatic islet organoids are expected to be a considerable source of islet transplantation. To construct human islet-like organoids, the seeding cells, biomaterials and three-dimensional structure are three key elements. Herein, this review summarizes current progresses about the cell origins, biomaterials and advanced technology being applied to make human islet organoids, and discusses the advantages, shortcomings, and future challenges of them as well. We hope this review can offer a cross-disciplinary perspective to build human islet organoids and provide insights for tissue engineering and regenerative medicine.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher Pty Ltd</pub><pmid>35198056</pmid><doi>10.7150/thno.66670</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biocompatible Materials Biomedical materials Collagen Diabetes Glucose Humans Hydrogels Hyperglycemia Insulin Islets of Langerhans Islets of Langerhans Transplantation Organoids Pancreas Review Technology Tissue engineering |
| title | Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies |
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