Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts

Basement membranes (BMs) are specialised extracellular matrices that provide structural support to tissues as well as influence cell behaviour and signalling. Mutations in COL4A1/COL4A2, a major BM component, cause a familial form of eye, kidney and cerebrovascular disease, including stroke, while c...

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Veröffentlicht in:	Biomaterials 2020-09, Vol.252, p.120090-120090, Article 120090
Hauptverfasser:	Ngandu Mpoyi, Elie, Cantini, Marco, Sin, Yuan Yan, Fleming, Lauren, Zhou, Dennis W., Costell, Mercedes, Lu, Yinhui, Kadler, Karl, García, Andrés J., Van Agtmael, Tom, Salmeron-Sanchez, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Basement Membrane Cell adhesion Cerebrovascular disease Collagen IV Collagen Type IV - genetics Disease mechanism Extracellular Matrix Fibroblasts Fibronectins - genetics Humans Mutation Protein folding
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