5-arylalkynyl-2-benzoyl thiophene: a novel microtubule inhibitor exhibits antitumor activity without neurological toxicity

The composition of microtubules involving several steps, including the polymerization and depolymerization of α-tubulin and β-tubulin heterodimers. Microtubule-targeting agents can increase or inhibit microtubule polymerization, thereby disrupting the dynamic process and stalling cells in G2/M phase...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	American journal of cancer research 2022-01, Vol.12 (1), p.229-246
Hauptverfasser:	Zhuang, Yuxin, Yang, Guang, Wu, Shaoyu, Chen, Jianjun, Guo, Jiayin, Quan, Dongling, Zhang, Tingting, Yang, Zichao, Tan, Shaobin, Ji, Yuheng, Chen, Zhipeng, Lv, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!