Bone marrow mesenchymal stem cell-derived exosomal miR-34c-5p ameliorates RIF by inhibiting the core fucosylation of multiple proteins

Renal interstitial fibrosis (RIF) is an incurable pathological lesion in chronic kidney diseases. Pericyte activation is the major pathological characteristic of RIF. Fibroblast and macrophage activation are also involved in RIF. Studies have revealed that core fucosylation (CF), an important post-t...

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Veröffentlicht in:	Molecular therapy 2022-02, Vol.30 (2), p.763-781
Hauptverfasser:	Hu, Xuemei, Shen, Nan, Liu, Anqi, Wang, Weidong, Zhang, Lihua, Sui, Zhigang, Tang, Qingzhu, Du, Xiangning, Yang, Ning, Ying, Wantao, Qin, Biaojie, Li, Zhitong, Li, Lin, Wang, Nan, Lin, Hongli
Format:	Artikel
Sprache:	eng
Schlagworte:	core fucosylation exosomes Exosomes - metabolism Fibrosis Humans Kidney - pathology Kidney Diseases - metabolism Kidney Diseases - therapy mesenchymal stem cells Mesenchymal Stem Cells - metabolism microRNA-34c-5p MicroRNAs - administration & dosage MicroRNAs - genetics MicroRNAs - metabolism Original pericyte renal interstitial fibrosis
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