FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by Regulating ABCC5 Gene Transcription

Objective. The aim of the present study was to investigate the effect of forkhead box M1 (FOXM1) to paclitaxel resistance in cervical cancer cells, to determine the underlying mechanism, and to identify novel targets for the treatment of paclitaxel-resistant cervical cancer. Methods. Paclitaxel-resi...

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Veröffentlicht in:	BioMed research international 2022, Vol.2022 (1), p.3032590-3032590
Hauptverfasser:	Hou, Youxiang, Dong, Zhanfei, Zhong, Wei, Yin, Linglong, Li, Xiong, Kuerban, Gulina, Huang, He
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Cancer Cancer therapies Cell culture Cell cycle Cell Cycle - drug effects Cell death Cell division Cell Line, Tumor Cell migration Cell Movement - drug effects Cervical cancer Cervix Cloning Drug resistance Drug Resistance, Neoplasm - genetics Drug therapy Female Flow cytometry Forkhead Box Protein M1 - genetics Forkhead protein Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Health aspects Humans Intracellular Laboratories Membrane proteins Membranes Multidrug Resistance-Associated Proteins - genetics Paclitaxel Paclitaxel - pharmacology Physiological aspects Proteins Siomycin A Target recognition Taxol Transcription Transcription, Genetic - drug effects Uterine Cervical Neoplasms - genetics Wound healing
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