Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy

We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-proliferative therapies. Functional characterization of spontaneous glioblastomas from genetically engineered mice reveals essential quiescent stem-like cells that can be directly isolated from tumors. A der...

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Veröffentlicht in:	Developmental cell 2022-01, Vol.57 (1), p.32-46.e8
Hauptverfasser:	Xie, Xuanhua P., Laks, Dan R., Sun, Daochun, Ganbold, Mungunsarnai, Wang, Zilai, Pedraza, Alicia M., Bale, Tejus, Tabar, Viviane, Brennan, Cameron, Zhou, Xiuping, Parada, Luis F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - metabolism Brain Neoplasms - pathology cancer stem cells Cell Cycle - genetics Cell Division - physiology Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Cell Survival - physiology Cell Transformation, Neoplastic - pathology chemoresistance F3 receptor Gene Expression - genetics Gene Expression Regulation, Neoplastic - genetics glioblastoma Glioblastoma - metabolism Glioblastoma - pathology heterogeneity Heterografts Humans Mice Neoplasm Invasiveness - genetics Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology quiescence recurrence single-cell RNA sequencing temozolomide Transcriptome - genetics
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