Exposure to an Environmental Mixture of Polycyclic Aromatic Hydrocarbons Induces Hepatic Cytochrome P450 Enzymes in Mice

Cytochrome P450 enzymes (CYPs) play an important role in bioactivating or detoxifying polycyclic aromatic hydrocarbons (PAHs), common environmental contaminants. While it is widely accepted that exposure to PAHs induces CYPs, effectively increasing rates of xenobiotic metabolism, dose- and time-resp...

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Veröffentlicht in:	Chemical research in toxicology 2021-09, Vol.34 (9), p.2145-2156
Hauptverfasser:	Stoddard, Ethan G, Nag, Subhasree, Martin, Jude, Tyrrell, Kimberly J, Gibbins, Teresa, Anderson, Kim A, Shukla, Anil K, Corley, Richard, Wright, Aaron T, Smith, Jordan N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzo(a)pyrene - metabolism Cytochrome P-450 Enzyme System - metabolism Female Liver - enzymology Liver - metabolism Mice Microsomes, Liver - enzymology Microsomes, Liver - metabolism Proteome - metabolism Proteomics
Online-Zugang:	Volltext
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