Syndecan-4 affects myogenesis via Rac1-mediated actin remodeling and exhibits copy-number amplification and increased expression in human rhabdomyosarcoma tumors

Skeletal muscle demonstrates a high degree of regenerative capacity repeating the embryonic myogenic program under strict control. Rhabdomyosarcoma is the most common sarcoma in childhood and is characterized by impaired muscle differentiation. In this study, we observed that silencing the expressio...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2022-02, Vol.79 (2), p.122-122, Article 122
Hauptverfasser:	Szabo, Kitti, Varga, Daniel, Vegh, Attila Gergely, Liu, Ning, Xiao, Xue, Xu, Lin, Dux, Laszlo, Erdelyi, Miklos, Rovo, Laszlo, Keller-Pinter, Aniko
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton Actins - metabolism Amplification Animals Atomic force microscopy Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell Differentiation Cell fusion Cell Line Children Cytoskeleton Differentiation DNA Copy Number Variations Embryos Gene expression Gene sequencing Heparan sulfate Humans Life Sciences Male Mice Microscopy Muscle Development Muscle, Skeletal - metabolism Muscles Musculoskeletal system Myoblasts Myoblasts - cytology Myoblasts - metabolism Myogenesis Original Original Article Proteoglycans rac1 GTP-Binding Protein - metabolism Rac1 protein Rats Rats, Wistar Regeneration Rhabdomyosarcoma Rhabdomyosarcoma - metabolism Rhabdomyosarcoma - pathology RNA Interference RNA, Small Interfering - metabolism Sarcoma Skeletal muscle Stochasticity Syndecan Syndecan-4 - antagonists & inhibitors Syndecan-4 - genetics Syndecan-4 - metabolism T-Lymphoma Invasion and Metastasis-inducing Protein 1 - metabolism Tumorigenesis Tumors
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