Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance

The F-box and WD-repeat-containing protein 2 (FBXW2) plays a crucial role as an E3 ligase in regulating tumorigenesis. However, the functions of FBXW2 in breast cancer are still unknown. Here, we find that nuclear factor-kB (NF-κB) p65 is a new substrate of FBXW2. FBXW2 directly binds to p65, leadin...

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Veröffentlicht in:	Cell death and differentiation 2022-02, Vol.29 (2), p.381-392
Hauptverfasser:	Ren, Chune, Han, Xue, Lu, Chao, Yang, Tingting, Qiao, Pengyun, Sun, Yonghong, Yu, Zhenhai
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/95 38/77 42/89 45/23 45/90 631/337/475/2290 631/67/1244 692/53/2421 692/699/67/327 82/58 82/83 96/109 Acetylation Animals Apoptosis Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cell Biology Cell Cycle Analysis Cell Transformation, Neoplastic Degradation F-Box Proteins - genetics F-Box Proteins - metabolism Female Humans Life Sciences Mice NF-kappa B - metabolism NF-κB protein Paclitaxel Paclitaxel - pharmacology Paclitaxel - therapeutic use Stem Cells Transcription Factor RelA - metabolism Tumor suppressor genes Tumorigenesis Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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