Therapeutic Targets of Bufalin on Renal Carcinoma and Mechanisms: Experimental Validation of Network Pharmacology Analysis

The possible targets underlying the activity of bufalin on renal cell carcinoma (RCC) were investigated using network pharmacology and experimental approaches. PharmMapper and other databases were explored for predicting the bufalin targets and RCC-related targets. Finally, the enriched pathways and...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2022, Vol.2022, p.5469795-10
Hauptverfasser:	Zhang, Lei, Pan, Yi-Ming, Wang, Lu-Yao, Zhao, Wan-Zhu, Yang, Shao-Cheng, Sun, Xue-Fang, Guan, Xin, Yan, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Analgesics Apoptosis Bioinformatics Bladder cancer Cancer therapies Cell cycle Cell growth Chinese medicine Drug dosages Esophagus Gene expression Genomes Kidney cancer Kinases MAP kinase Medical research Mesangial cells Morphology Pharmacology Proteins Renal cell carcinoma Signal transduction Therapeutic applications Therapeutic targets Tumors
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