Effects of imidazoline agents in a rat conditioned place preference model of addiction
Agmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The present study aimed to evaluate the interaction between AG, IDZ, and EFR with an opiate, tramadol (TR), in a conditioned place preference (CPP) paradigm...
Gespeichert in:
| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 2022-03, Vol.395 (3), p.365-376 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 376 |
|---|---|
| container_issue | 3 |
| container_start_page | 365 |
| container_title | Naunyn-Schmiedeberg's archives of pharmacology |
| container_volume | 395 |
| creator | Şorodoc, V. Rusu-Zota, G. Nechita, P. Moraru, C. Manole, O. M. |
| description | Agmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The present study aimed to evaluate the interaction between AG, IDZ, and EFR with an opiate, tramadol (TR), in a conditioned place preference (CPP) paradigm. In the experiment, we used five groups with 8 adult male Wistar rats each. During the condition session, on days 2, 4, 6, and 8, the rats received the drugs (saline, or TR, or IDZ and TR, or EFR and TR, or AG and TR) and were placed in their least preferred compartment. On days 1, 3, 5, and 7, the rats received saline in the preferred compartment. In the preconditioning, the preferred compartment was determined. In the postconditioning, the preference for one of the compartments was reevaluated. TR increased the time spent in the non-preferred compartment. AG decreased time spent in the TR-paired compartment. EFR, more than IDZ, reduced the time spent in the TR-paired compartment, but without statistical significance. AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in the TR-paired compartment, without statistical significance
. |
| doi_str_mv | 10.1007/s00210-021-02194-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8816376</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2625411495</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-970165a894d30e9d93857c00ad7a1dba3c47ce0049f7f244b8952749cb7997143</originalsourceid><addsrcrecordid>eNp9UU1PxCAQJUbjrqt_wINp4rkKlJZyMTGb9SMx8aJeCQW6smmhQtfE_fVSu6568cAwYd68eY8B4BTBCwQhvQwQYgTTGIbDSLrZA1NEMpwihvA-mMZ6mSLMygk4CmEFISxQnh-CSUYYo5jiKXhZ1LWWfUhcnZjWKLFxjbE6EUtt46uxiUi86BPprDK9cVarpGuE1Ennda29tjFtndLNwCCUMnJAHYODWjRBn2zvGXi-WTzN79KHx9v7-fVDKgklfcooREUuSkZUBjVTLCtzKiEUigqkKpFFmNQQElbTGhNSlSzHlDBZ0WggWp2Bq5G3W1etVjKK9qLhnTet8B_cCcP_Vqx55Uv3zssSFRktIsH5lsC7t7UOPV-5tbdRM8cFzglChOURhUeU9C6EaHw3AUE-7IKPu-Ax8K9d8E1sOvutbdfy_fkRkI2AEEt2qf3P7H9oPwHdl5WN</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2625411495</pqid></control><display><type>article</type><title>Effects of imidazoline agents in a rat conditioned place preference model of addiction</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Şorodoc, V. ; Rusu-Zota, G. ; Nechita, P. ; Moraru, C. ; Manole, O. M.</creator><creatorcontrib>Şorodoc, V. ; Rusu-Zota, G. ; Nechita, P. ; Moraru, C. ; Manole, O. M.</creatorcontrib><description>Agmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The present study aimed to evaluate the interaction between AG, IDZ, and EFR with an opiate, tramadol (TR), in a conditioned place preference (CPP) paradigm. In the experiment, we used five groups with 8 adult male Wistar rats each. During the condition session, on days 2, 4, 6, and 8, the rats received the drugs (saline, or TR, or IDZ and TR, or EFR and TR, or AG and TR) and were placed in their least preferred compartment. On days 1, 3, 5, and 7, the rats received saline in the preferred compartment. In the preconditioning, the preferred compartment was determined. In the postconditioning, the preference for one of the compartments was reevaluated. TR increased the time spent in the non-preferred compartment. AG decreased time spent in the TR-paired compartment. EFR, more than IDZ, reduced the time spent in the TR-paired compartment, but without statistical significance. AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in the TR-paired compartment, without statistical significance
.</description><identifier>ISSN: 0028-1298</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/s00210-021-02194-z</identifier><identifier>PMID: 34997272</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Addictions ; Agmatine ; Agmatine - pharmacology ; Analgesics, Opioid - pharmacology ; Animal models ; Animals ; Benzofurans - pharmacology ; Biomedical and Life Sciences ; Biomedicine ; Central nervous system ; Conditioning, Psychological - drug effects ; Drug Interactions ; Idazoxan - pharmacology ; Imidazoles - pharmacology ; Imidazoline ; Imidazoline Receptors - drug effects ; Imidazoline Receptors - metabolism ; Male ; Neurosciences ; Original ; Original Article ; Pharmacology/Toxicology ; Place preference conditioning ; Rats ; Rats, Wistar ; Rodents ; Statistics ; Time Factors ; Tramadol ; Tramadol - pharmacology</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 2022-03, Vol.395 (3), p.365-376</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-970165a894d30e9d93857c00ad7a1dba3c47ce0049f7f244b8952749cb7997143</citedby><cites>FETCH-LOGICAL-c474t-970165a894d30e9d93857c00ad7a1dba3c47ce0049f7f244b8952749cb7997143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00210-021-02194-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00210-021-02194-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34997272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Şorodoc, V.</creatorcontrib><creatorcontrib>Rusu-Zota, G.</creatorcontrib><creatorcontrib>Nechita, P.</creatorcontrib><creatorcontrib>Moraru, C.</creatorcontrib><creatorcontrib>Manole, O. M.</creatorcontrib><title>Effects of imidazoline agents in a rat conditioned place preference model of addiction</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn-Schmiedeberg's Arch Pharmacol</addtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description>Agmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The present study aimed to evaluate the interaction between AG, IDZ, and EFR with an opiate, tramadol (TR), in a conditioned place preference (CPP) paradigm. In the experiment, we used five groups with 8 adult male Wistar rats each. During the condition session, on days 2, 4, 6, and 8, the rats received the drugs (saline, or TR, or IDZ and TR, or EFR and TR, or AG and TR) and were placed in their least preferred compartment. On days 1, 3, 5, and 7, the rats received saline in the preferred compartment. In the preconditioning, the preferred compartment was determined. In the postconditioning, the preference for one of the compartments was reevaluated. TR increased the time spent in the non-preferred compartment. AG decreased time spent in the TR-paired compartment. EFR, more than IDZ, reduced the time spent in the TR-paired compartment, but without statistical significance. AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in the TR-paired compartment, without statistical significance
.</description><subject>Addictions</subject><subject>Agmatine</subject><subject>Agmatine - pharmacology</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animal models</subject><subject>Animals</subject><subject>Benzofurans - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Central nervous system</subject><subject>Conditioning, Psychological - drug effects</subject><subject>Drug Interactions</subject><subject>Idazoxan - pharmacology</subject><subject>Imidazoles - pharmacology</subject><subject>Imidazoline</subject><subject>Imidazoline Receptors - drug effects</subject><subject>Imidazoline Receptors - metabolism</subject><subject>Male</subject><subject>Neurosciences</subject><subject>Original</subject><subject>Original Article</subject><subject>Pharmacology/Toxicology</subject><subject>Place preference conditioning</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Statistics</subject><subject>Time Factors</subject><subject>Tramadol</subject><subject>Tramadol - pharmacology</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9UU1PxCAQJUbjrqt_wINp4rkKlJZyMTGb9SMx8aJeCQW6smmhQtfE_fVSu6568cAwYd68eY8B4BTBCwQhvQwQYgTTGIbDSLrZA1NEMpwihvA-mMZ6mSLMygk4CmEFISxQnh-CSUYYo5jiKXhZ1LWWfUhcnZjWKLFxjbE6EUtt46uxiUi86BPprDK9cVarpGuE1Ennda29tjFtndLNwCCUMnJAHYODWjRBn2zvGXi-WTzN79KHx9v7-fVDKgklfcooREUuSkZUBjVTLCtzKiEUigqkKpFFmNQQElbTGhNSlSzHlDBZ0WggWp2Bq5G3W1etVjKK9qLhnTet8B_cCcP_Vqx55Uv3zssSFRktIsH5lsC7t7UOPV-5tbdRM8cFzglChOURhUeU9C6EaHw3AUE-7IKPu-Ax8K9d8E1sOvutbdfy_fkRkI2AEEt2qf3P7H9oPwHdl5WN</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Şorodoc, V.</creator><creator>Rusu-Zota, G.</creator><creator>Nechita, P.</creator><creator>Moraru, C.</creator><creator>Manole, O. M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20220301</creationdate><title>Effects of imidazoline agents in a rat conditioned place preference model of addiction</title><author>Şorodoc, V. ; Rusu-Zota, G. ; Nechita, P. ; Moraru, C. ; Manole, O. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-970165a894d30e9d93857c00ad7a1dba3c47ce0049f7f244b8952749cb7997143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Addictions</topic><topic>Agmatine</topic><topic>Agmatine - pharmacology</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Animal models</topic><topic>Animals</topic><topic>Benzofurans - pharmacology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Central nervous system</topic><topic>Conditioning, Psychological - drug effects</topic><topic>Drug Interactions</topic><topic>Idazoxan - pharmacology</topic><topic>Imidazoles - pharmacology</topic><topic>Imidazoline</topic><topic>Imidazoline Receptors - drug effects</topic><topic>Imidazoline Receptors - metabolism</topic><topic>Male</topic><topic>Neurosciences</topic><topic>Original</topic><topic>Original Article</topic><topic>Pharmacology/Toxicology</topic><topic>Place preference conditioning</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Statistics</topic><topic>Time Factors</topic><topic>Tramadol</topic><topic>Tramadol - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Şorodoc, V.</creatorcontrib><creatorcontrib>Rusu-Zota, G.</creatorcontrib><creatorcontrib>Nechita, P.</creatorcontrib><creatorcontrib>Moraru, C.</creatorcontrib><creatorcontrib>Manole, O. M.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Şorodoc, V.</au><au>Rusu-Zota, G.</au><au>Nechita, P.</au><au>Moraru, C.</au><au>Manole, O. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of imidazoline agents in a rat conditioned place preference model of addiction</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><stitle>Naunyn-Schmiedeberg's Arch Pharmacol</stitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>395</volume><issue>3</issue><spage>365</spage><epage>376</epage><pages>365-376</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><abstract>Agmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The present study aimed to evaluate the interaction between AG, IDZ, and EFR with an opiate, tramadol (TR), in a conditioned place preference (CPP) paradigm. In the experiment, we used five groups with 8 adult male Wistar rats each. During the condition session, on days 2, 4, 6, and 8, the rats received the drugs (saline, or TR, or IDZ and TR, or EFR and TR, or AG and TR) and were placed in their least preferred compartment. On days 1, 3, 5, and 7, the rats received saline in the preferred compartment. In the preconditioning, the preferred compartment was determined. In the postconditioning, the preference for one of the compartments was reevaluated. TR increased the time spent in the non-preferred compartment. AG decreased time spent in the TR-paired compartment. EFR, more than IDZ, reduced the time spent in the TR-paired compartment, but without statistical significance. AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in the TR-paired compartment, without statistical significance
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34997272</pmid><doi>10.1007/s00210-021-02194-z</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-1298 |
| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 2022-03, Vol.395 (3), p.365-376 |
| issn | 0028-1298 1432-1912 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8816376 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Addictions Agmatine Agmatine - pharmacology Analgesics, Opioid - pharmacology Animal models Animals Benzofurans - pharmacology Biomedical and Life Sciences Biomedicine Central nervous system Conditioning, Psychological - drug effects Drug Interactions Idazoxan - pharmacology Imidazoles - pharmacology Imidazoline Imidazoline Receptors - drug effects Imidazoline Receptors - metabolism Male Neurosciences Original Original Article Pharmacology/Toxicology Place preference conditioning Rats Rats, Wistar Rodents Statistics Time Factors Tramadol Tramadol - pharmacology |
| title | Effects of imidazoline agents in a rat conditioned place preference model of addiction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T10%3A37%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20imidazoline%20agents%20in%20a%20rat%20conditioned%20place%20preference%20model%20of%20addiction&rft.jtitle=Naunyn-Schmiedeberg's%20archives%20of%20pharmacology&rft.au=%C5%9Eorodoc,%20V.&rft.date=2022-03-01&rft.volume=395&rft.issue=3&rft.spage=365&rft.epage=376&rft.pages=365-376&rft.issn=0028-1298&rft.eissn=1432-1912&rft_id=info:doi/10.1007/s00210-021-02194-z&rft_dat=%3Cproquest_pubme%3E2625411495%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2625411495&rft_id=info:pmid/34997272&rfr_iscdi=true |