Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker

Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker

Construction of larger molecular libraries on an addressable microelectrode array requires a method for recovering and characterizing molecules from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. We report here a metho...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2021-07, Vol.23 (14), p.5440-5444
Hauptverfasser: Yeh, Nai-Hua, Krueger, Ruby, Moeller, Kevin D
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemical synthesis
Alkenes - chemistry
Microelectrodes
Molecular Structure
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 5444
container_issue 14
container_start_page 5440
container_title Organic letters
container_volume 23
creator Yeh, Nai-Hua
Krueger, Ruby
Moeller, Kevin D
description Construction of larger molecular libraries on an addressable microelectrode array requires a method for recovering and characterizing molecules from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. We report here a method for achieving this goal that employs the site-selective dihydroxylation reaction of a simple olefin.
doi_str_mv 10.1021/acs.orglett.1c01675
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8815274</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2546600218</sourcerecordid><originalsourceid>FETCH-LOGICAL-a445t-be5739daf4c0369f4a98026861d44361c0c4e52109ad285e038337260093efdf3</originalsourceid><addsrcrecordid>eNp9UctOIzEQtBArXssXICEfOTDBz3lckFDCS8qKw-6ejePpyQw442A7iPl7HCVE7GVP3WpXVberEDqjZEQJo1fahJHzcwsxjqghNC_kHjqikvGsIJLt7_qcHKLjEF4IoWlSHaBDLmgpJOdH6PlXZ7wDCyZ6VwO-8V4P4RJPunaovfsYrI6d6y-x7mscW8ATeAfrlgvoI3ZNGuMnH1s3d722-LduIA7ZWEfT4mnXv4L_iX402gY43dYT9Pfu9s_4IZs-3T-Ob6aZFkLGbAay4FWtG2EIz6tG6KokLC9zWgvB8_Q_I0AySipds1IC4SXnBcsJqTg0dcNP0PVGd7maLaA26T6vrVr6bqH9oJzu1L8vfdequXtXZZlMKUQSuNgKePe2ghDVogsGrNU9uFVQTIo8rWO0TFC-gSbrQvDQ7NZQotbZqJSN2majttkk1vn3C3ecrzAS4GoDWLNf3MonS8N_JT8BMSie9w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2546600218</pqid></control><display><type>article</type><title>Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker</title><source>MEDLINE</source><source>ACS Publications</source><creator>Yeh, Nai-Hua ; Krueger, Ruby ; Moeller, Kevin D</creator><creatorcontrib>Yeh, Nai-Hua ; Krueger, Ruby ; Moeller, Kevin D</creatorcontrib><description>Construction of larger molecular libraries on an addressable microelectrode array requires a method for recovering and characterizing molecules from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. We report here a method for achieving this goal that employs the site-selective dihydroxylation reaction of a simple olefin.</description><identifier>ISSN: 1523-7060</identifier><identifier>EISSN: 1523-7052</identifier><identifier>DOI: 10.1021/acs.orglett.1c01675</identifier><identifier>PMID: 34184533</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Alkenes - chemical synthesis ; Alkenes - chemistry ; Microelectrodes ; Molecular Structure</subject><ispartof>Organic letters, 2021-07, Vol.23 (14), p.5440-5444</ispartof><rights>2021 American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a445t-be5739daf4c0369f4a98026861d44361c0c4e52109ad285e038337260093efdf3</citedby><cites>FETCH-LOGICAL-a445t-be5739daf4c0369f4a98026861d44361c0c4e52109ad285e038337260093efdf3</cites><orcidid>0000-0002-3893-5923</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.orglett.1c01675$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.orglett.1c01675$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2763,27074,27922,27923,56736,56786</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34184533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeh, Nai-Hua</creatorcontrib><creatorcontrib>Krueger, Ruby</creatorcontrib><creatorcontrib>Moeller, Kevin D</creatorcontrib><title>Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker</title><title>Organic letters</title><addtitle>Org. Lett</addtitle><description>Construction of larger molecular libraries on an addressable microelectrode array requires a method for recovering and characterizing molecules from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. We report here a method for achieving this goal that employs the site-selective dihydroxylation reaction of a simple olefin.</description><subject>Alkenes - chemical synthesis</subject><subject>Alkenes - chemistry</subject><subject>Microelectrodes</subject><subject>Molecular Structure</subject><issn>1523-7060</issn><issn>1523-7052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctOIzEQtBArXssXICEfOTDBz3lckFDCS8qKw-6ejePpyQw442A7iPl7HCVE7GVP3WpXVberEDqjZEQJo1fahJHzcwsxjqghNC_kHjqikvGsIJLt7_qcHKLjEF4IoWlSHaBDLmgpJOdH6PlXZ7wDCyZ6VwO-8V4P4RJPunaovfsYrI6d6y-x7mscW8ATeAfrlgvoI3ZNGuMnH1s3d722-LduIA7ZWEfT4mnXv4L_iX402gY43dYT9Pfu9s_4IZs-3T-Ob6aZFkLGbAay4FWtG2EIz6tG6KokLC9zWgvB8_Q_I0AySipds1IC4SXnBcsJqTg0dcNP0PVGd7maLaA26T6vrVr6bqH9oJzu1L8vfdequXtXZZlMKUQSuNgKePe2ghDVogsGrNU9uFVQTIo8rWO0TFC-gSbrQvDQ7NZQotbZqJSN2majttkk1vn3C3ecrzAS4GoDWLNf3MonS8N_JT8BMSie9w</recordid><startdate>20210716</startdate><enddate>20210716</enddate><creator>Yeh, Nai-Hua</creator><creator>Krueger, Ruby</creator><creator>Moeller, Kevin D</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3893-5923</orcidid></search><sort><creationdate>20210716</creationdate><title>Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker</title><author>Yeh, Nai-Hua ; Krueger, Ruby ; Moeller, Kevin D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a445t-be5739daf4c0369f4a98026861d44361c0c4e52109ad285e038337260093efdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alkenes - chemical synthesis</topic><topic>Alkenes - chemistry</topic><topic>Microelectrodes</topic><topic>Molecular Structure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, Nai-Hua</creatorcontrib><creatorcontrib>Krueger, Ruby</creatorcontrib><creatorcontrib>Moeller, Kevin D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Organic letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, Nai-Hua</au><au>Krueger, Ruby</au><au>Moeller, Kevin D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker</atitle><jtitle>Organic letters</jtitle><addtitle>Org. Lett</addtitle><date>2021-07-16</date><risdate>2021</risdate><volume>23</volume><issue>14</issue><spage>5440</spage><epage>5444</epage><pages>5440-5444</pages><issn>1523-7060</issn><eissn>1523-7052</eissn><abstract>Construction of larger molecular libraries on an addressable microelectrode array requires a method for recovering and characterizing molecules from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. We report here a method for achieving this goal that employs the site-selective dihydroxylation reaction of a simple olefin.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>34184533</pmid><doi>10.1021/acs.orglett.1c01675</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3893-5923</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1523-7060
ispartof Organic letters, 2021-07, Vol.23 (14), p.5440-5444
issn 1523-7060
1523-7052
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8815274
source MEDLINE; ACS Publications
subjects Alkenes - chemical synthesis
Alkenes - chemistry
Microelectrodes
Molecular Structure
title Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T09%3A41%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microelectrode%20Arrays,%20Dihydroxylation,%20and%20the%20Development%20of%20an%20Orthogonal%20Safety-Catch%20Linker&rft.jtitle=Organic%20letters&rft.au=Yeh,%20Nai-Hua&rft.date=2021-07-16&rft.volume=23&rft.issue=14&rft.spage=5440&rft.epage=5444&rft.pages=5440-5444&rft.issn=1523-7060&rft.eissn=1523-7052&rft_id=info:doi/10.1021/acs.orglett.1c01675&rft_dat=%3Cproquest_pubme%3E2546600218%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2546600218&rft_id=info:pmid/34184533&rfr_iscdi=true