Venetoclax plus dose-adjusted R-EPOCH for Richter syndrome

Richter syndrome (RS) of chronic lymphocytic leukemia (CLL) is typically chemoresistant, with a poor prognosis. We hypothesized that the oral Bcl-2 inhibitor venetoclax could sensitize RS to chemoimmunotherapy and improve outcomes. We conducted a single-arm, investigator-sponsored, phase 2 trial of...

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Veröffentlicht in:	Blood 2022-02, Vol.139 (5), p.686-689
Hauptverfasser:	Davids, Matthew S., Rogers, Kerry A., Tyekucheva, Svitlana, Wang, Zixu, Pazienza, Samantha, Renner, Sarah K., Montegaard, Josie, Ihuoma, Udochukwu, Lehmberg, Timothy Z., Parry, Erin M., Wu, Catherine J., Jacobson, Caron A., Fisher, David C., Thompson, Philip A., Brown, Jennifer R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Bridged Bicyclo Compounds, Heterocyclic - adverse effects Bridged Bicyclo Compounds, Heterocyclic - therapeutic use Clinical Trials and Observations Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Cyclophosphamide - therapeutic use Doxorubicin - administration & dosage Doxorubicin - adverse effects Doxorubicin - therapeutic use Etoposide - administration & dosage Etoposide - adverse effects Etoposide - therapeutic use Female Humans Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Lymphoma, Large B-Cell, Diffuse - drug therapy Male Middle Aged Neutropenia - chemically induced Prednisone - administration & dosage Prednisone - adverse effects Prednisone - therapeutic use Progression-Free Survival Sulfonamides - administration & dosage Sulfonamides - adverse effects Sulfonamides - therapeutic use Vincristine - administration & dosage Vincristine - adverse effects Vincristine - therapeutic use
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