XPS and ToF‐SIMS Characterization of New Biodegradable Poly(Peptide‐Urethane‐Urea) Block Copolymers

New, linear, segmented poly(peptide‐urethane‐urea) (PPUU) block copolymers are synthesized and their surface compositions are characterized with angle dependent X‐ray photoelectron spectroscopy (ADXPS) and time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). These new PPUU block copolymers contain three types of segments. The soft segment (SS) is poly(caprolactone diol) (PCL). The hard segment is lysine diisocyanate with a hydrazine chain extender. The oligopeptide segment (OPS) contains three types of amino acids (proline, hydroxyproline, and glycine). Incorporation of the OPS into the polyurethane backbone is done to provide a synthetic polymer material with controllable biodegradation properties. As biodegradation processes normally are initiated at the interface between the biomaterial and the living tissue, it is important to characterize the surface composition of biomaterials. ADXPS and ToF‐SIMS results show that the surfaces of all four polymers are enriched with the PCL SS, the most hydrophobic component of the three polymer segments. The synthesis and surface characterization of new linear segmented poly(peptide‐urethane‐urea) block copolymers are designed with three types of segments to provide controllable biodegradation properties. The poly(caprolactone diol) soft segment is surface enriched in the polymers. The hard segment is lysine diisocyanate with a hydrazine chain extender. The oligopeptide segment contained three amino acids (proline, hydroxyproline, and glycine).