Phase I/Ib Study of the Efficacy and Safety of Buparlisib and Ibrutinib Therapy in MCL, FL, and DLBCL with Serial Cell-Free DNA Monitoring

Activation of Bruton tyrosine kinase (BTK) and phosphatidylinositol-3-kinase (PI3K) represent parallel, synergistic pathways in lymphoma pathogenesis. As predominant PI3Kδ inhibition is a possible mechanism of tumor escape, we proposed a clinical trial of dual BTK and pan-PI3K inhibition. We conduct...

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Veröffentlicht in:	Clinical cancer research 2022-01, Vol.28 (1), p.45-56
Hauptverfasser:	Stewart, Caitlin M, Michaud, Laure, Whiting, Karissa, Nakajima, Reiko, Nichols, Chelsea, De Frank, Stephanie, Hamlin, Jr, Paul A, Matasar, Matthew J, Gerecitano, John F, Drullinsky, Pamela, Hamilton, Audrey, Straus, David, Horwitz, Steven M, Kumar, Anita, Moskowitz, Craig H, Moskowitz, Alison, Zelenetz, Andrew D, Rademaker, Jurgen, Salles, Gilles, Seshan, Venkatraman, Schöder, Heiko, Younes, Anas, Tsui, Dana W Y, Batlevi, Connie Lee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adult Aminopyridines Antineoplastic Combined Chemotherapy Protocols - adverse effects Cell-Free Nucleic Acids Humans Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Mantle-Cell - drug therapy Lymphoma, Mantle-Cell - genetics Lymphoma, Mantle-Cell - pathology Morpholines Phosphatidylinositol 3-Kinases Piperidines Pyrazoles Pyrimidines
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