PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism
Plants are agile, plastic organisms able to adapt to everchanging circumstances. Responding to far-red (FR) wavelengths from nearby vegetation, shade-intolerant species elicit the adaptive shade-avoidance syndrome (SAS), characterized by elongated petioles, leaf hyponasty, and smaller leaves. We uti...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2022-02, Vol.119 (5) |
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| creator | Hussain, Ejaz Romanowski, Andrés Halliday, Karen J |
| description | Plants are agile, plastic organisms able to adapt to everchanging circumstances. Responding to far-red (FR) wavelengths from nearby vegetation, shade-intolerant species elicit the adaptive shade-avoidance syndrome (SAS), characterized by elongated petioles, leaf hyponasty, and smaller leaves. We utilized end-of-day FR (EODFR) treatments to interrogate molecular processes that underlie the SAS leaf response. Genetic analysis established that PHYTOCHROME-INTERACTING FACTOR 7 (PIF7) is required for EODFR-mediated constraint of leaf blade cell division, while EODFR messenger RNA sequencing data identified
(
) as a potential PIF7 target. We show that PIF7 can suppress
transcription by directly interacting with and sequestering AN3. We also establish that PIF7 and AN3 impose antagonistic control of gene expression via common
acting promoter motifs in several cell-cycle regulator genes. EODFR triggers the molecular substitution of AN3 to PIF7 at G-box/PBE-box promoter regions and a switch from promotion to repression of gene expression. |
| doi_str_mv | 10.1073/pnas.2115682119 |
| format | Article |
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(
) as a potential PIF7 target. We show that PIF7 can suppress
transcription by directly interacting with and sequestering AN3. We also establish that PIF7 and AN3 impose antagonistic control of gene expression via common
acting promoter motifs in several cell-cycle regulator genes. EODFR triggers the molecular substitution of AN3 to PIF7 at G-box/PBE-box promoter regions and a switch from promotion to repression of gene expression.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.2115682119</identifier><identifier>PMID: 35086930</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Arabidopsis - genetics ; Arabidopsis - metabolism ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Biological Sciences ; Cell division ; Cell proliferation ; Cell Proliferation - genetics ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Factor VII - genetics ; Gene expression ; Gene Expression - genetics ; Gene Expression Regulation, Plant - genetics ; Gene sequencing ; Genetic analysis ; Leaves ; mRNA ; Phytochrome - metabolism ; Plant Leaves - metabolism ; Promoter Regions, Genetic - genetics ; Sequestering ; Shade ; Substitutes ; Trans-Activators - genetics ; Trans-Activators - metabolism ; Transcription ; Wavelengths</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (5)</ispartof><rights>Copyright © 2022 the Author(s). Published by PNAS.</rights><rights>Copyright National Academy of Sciences Feb 1, 2022</rights><rights>Copyright © 2022 the Author(s). Published by PNAS. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-e3f98456c0c69aeb902591674c4a5fef92702bf3dd9a2e4f3537f3a6f9f36be43</citedby><cites>FETCH-LOGICAL-c487t-e3f98456c0c69aeb902591674c4a5fef92702bf3dd9a2e4f3537f3a6f9f36be43</cites><orcidid>0000-0003-0737-2408 ; 0000-0002-1127-5582</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812563/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812563/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35086930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hussain, Ejaz</creatorcontrib><creatorcontrib>Romanowski, Andrés</creatorcontrib><creatorcontrib>Halliday, Karen J</creatorcontrib><title>PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Plants are agile, plastic organisms able to adapt to everchanging circumstances. Responding to far-red (FR) wavelengths from nearby vegetation, shade-intolerant species elicit the adaptive shade-avoidance syndrome (SAS), characterized by elongated petioles, leaf hyponasty, and smaller leaves. We utilized end-of-day FR (EODFR) treatments to interrogate molecular processes that underlie the SAS leaf response. Genetic analysis established that PHYTOCHROME-INTERACTING FACTOR 7 (PIF7) is required for EODFR-mediated constraint of leaf blade cell division, while EODFR messenger RNA sequencing data identified
(
) as a potential PIF7 target. We show that PIF7 can suppress
transcription by directly interacting with and sequestering AN3. We also establish that PIF7 and AN3 impose antagonistic control of gene expression via common
acting promoter motifs in several cell-cycle regulator genes. EODFR triggers the molecular substitution of AN3 to PIF7 at G-box/PBE-box promoter regions and a switch from promotion to repression of gene expression.</description><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Biological Sciences</subject><subject>Cell division</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Factor VII - genetics</subject><subject>Gene expression</subject><subject>Gene Expression - genetics</subject><subject>Gene Expression Regulation, Plant - genetics</subject><subject>Gene sequencing</subject><subject>Genetic analysis</subject><subject>Leaves</subject><subject>mRNA</subject><subject>Phytochrome - metabolism</subject><subject>Plant Leaves - metabolism</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Sequestering</subject><subject>Shade</subject><subject>Substitutes</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - metabolism</subject><subject>Transcription</subject><subject>Wavelengths</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1PFTEUxRuikSe6ZkcmceNm4Pa73ZAQIkpC1AW4bTp9t7whM9OhnSHxv3dGENRNb5v7uyf39BBySOGYguYn4-DLMaNUKrOcdo9sKFhaK2HhFdkAMF0bwcQ-eVvKHQBYaeAN2ecSjLIcNuTH98sLXYU0TDl1perQxypg11Xj8m4jZj-1aaimXU7z7a7yQ3X2lVdlbsrUTvPvXsYxYynrtcew80Nb-nfkdfRdwfdP9YDcXHy6Pv9SX337fHl-dlUHYfRUI4_WCKkCBGU9NhaYtFRpEYSXEaNlGlgT-XZrPUMRueQ6cq-ijVw1KPgBOX3UHeemx23AxYfv3Jjb3uefLvnW_dsZ2p27TQ_OGMqk4ovAxyeBnO5nLJPr27J-gB8wzcUxxbixjCqzoB_-Q-_SnIfF3kppI7WBVfDkkQo5lZIxPi9Dwa2ZuTUz95LZMnH0t4dn_k9I_BeuS5Qj</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Hussain, Ejaz</creator><creator>Romanowski, Andrés</creator><creator>Halliday, Karen J</creator><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0737-2408</orcidid><orcidid>https://orcid.org/0000-0002-1127-5582</orcidid></search><sort><creationdate>20220201</creationdate><title>PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism</title><author>Hussain, Ejaz ; Romanowski, Andrés ; Halliday, Karen J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-e3f98456c0c69aeb902591674c4a5fef92702bf3dd9a2e4f3537f3a6f9f36be43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Biological Sciences</topic><topic>Cell division</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - genetics</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Factor VII - genetics</topic><topic>Gene expression</topic><topic>Gene Expression - genetics</topic><topic>Gene Expression Regulation, Plant - genetics</topic><topic>Gene sequencing</topic><topic>Genetic analysis</topic><topic>Leaves</topic><topic>mRNA</topic><topic>Phytochrome - metabolism</topic><topic>Plant Leaves - metabolism</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Sequestering</topic><topic>Shade</topic><topic>Substitutes</topic><topic>Trans-Activators - genetics</topic><topic>Trans-Activators - metabolism</topic><topic>Transcription</topic><topic>Wavelengths</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussain, Ejaz</creatorcontrib><creatorcontrib>Romanowski, Andrés</creatorcontrib><creatorcontrib>Halliday, Karen J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussain, Ejaz</au><au>Romanowski, Andrés</au><au>Halliday, Karen J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>119</volume><issue>5</issue><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Plants are agile, plastic organisms able to adapt to everchanging circumstances. Responding to far-red (FR) wavelengths from nearby vegetation, shade-intolerant species elicit the adaptive shade-avoidance syndrome (SAS), characterized by elongated petioles, leaf hyponasty, and smaller leaves. We utilized end-of-day FR (EODFR) treatments to interrogate molecular processes that underlie the SAS leaf response. Genetic analysis established that PHYTOCHROME-INTERACTING FACTOR 7 (PIF7) is required for EODFR-mediated constraint of leaf blade cell division, while EODFR messenger RNA sequencing data identified
(
) as a potential PIF7 target. We show that PIF7 can suppress
transcription by directly interacting with and sequestering AN3. We also establish that PIF7 and AN3 impose antagonistic control of gene expression via common
acting promoter motifs in several cell-cycle regulator genes. EODFR triggers the molecular substitution of AN3 to PIF7 at G-box/PBE-box promoter regions and a switch from promotion to repression of gene expression.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>35086930</pmid><doi>10.1073/pnas.2115682119</doi><orcidid>https://orcid.org/0000-0003-0737-2408</orcidid><orcidid>https://orcid.org/0000-0002-1127-5582</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Biological Sciences Cell division Cell proliferation Cell Proliferation - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Factor VII - genetics Gene expression Gene Expression - genetics Gene Expression Regulation, Plant - genetics Gene sequencing Genetic analysis Leaves mRNA Phytochrome - metabolism Plant Leaves - metabolism Promoter Regions, Genetic - genetics Sequestering Shade Substitutes Trans-Activators - genetics Trans-Activators - metabolism Transcription Wavelengths |
| title | PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism |
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