Natural history of Tay-Sachs disease in sheep

Tay-Sachs disease (TSD) is a fatal neurodegenerative disease caused by a deficiency of the enzyme β-N-acetylhexosaminidase A (HexA). TSD naturally occurs in Jacob sheep is the only experimental model of TSD. TSD in sheep recapitulates neurologic features similar to juvenile onset and late onset TSD...

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Veröffentlicht in:	Molecular genetics and metabolism 2021-09, Vol.134 (1-2), p.164-174
Hauptverfasser:	Story, Brett, Taghian, Toloo, Gallagher, Jillian, Koehler, Jey, Taylor, Amanda, Randle, Ashley, Nielsen, Kayly, Gross, Amanda, Maguire, Annie, Carl, Sara, Johnson, Siauna, Fernau, Deborah, Diffie, Elise, Cuddon, Paul, Corado, Carly, Chandra, Sundeep, Sena-Esteves, Miguel, Kolodny, Edwin, Jiang, Xuntian, Martin, Douglas, Gray-Edwards, Heather
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Brain - physiopathology Disease Models, Animal Large animal model Magnetic Resonance Imaging Neurodegeneration Sheep Tay-Sachs Tay-Sachs Disease - genetics Tay-Sachs Disease - physiopathology Tay-Sachs Disease - veterinary Translational Veterinary
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