Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study

Aims/hypothesis Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA 1c , that serve as early markers of type 2 diabetes progression may lead to a deeper understanding of the genetic aetiology of type 2 dia...

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Veröffentlicht in:	Diabetologia 2022-03, Vol.65 (3), p.477-489
Hauptverfasser:	Downie, Carolina G., Dimos, Sofia F., Bien, Stephanie A., Hu, Yao, Darst, Burcu F., Polfus, Linda M., Wang, Yujie, Wojcik, Genevieve L., Tao, Ran, Raffield, Laura M., Armstrong, Nicole D., Polikowsky, Hannah G., Below, Jennifer E., Correa, Adolfo, Irvin, Marguerite R., Rasmussen-Torvik, Laura J. F., Carlson, Christopher S., Phillips, Lawrence S., Liu, Simin, Pankow, James S., Rich, Stephen S., Rotter, Jerome I., Buyske, Steven, Matise, Tara C., North, Kari E., Avery, Christy L., Haiman, Christopher A., Loos, Ruth J. F., Kooperberg, Charles, Graff, Mariaelisa, Highland, Heather M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Glucose - genetics Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Epidemiology Fasting Gene mapping Genetic diversity Genome-Wide Association Study - methods Genomics Glucose Hemoglobin Human Physiology Humans Insulin Internal Medicine Laboratory testing Medicine Medicine & Public Health Metabolic Diseases Minority & ethnic groups Polymorphism, Single Nucleotide - genetics Population genetics Population studies Public health Statistical analysis
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