Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

The glucocorticoid (GC) receptor (GR) is essential for normal development and in the initiation of inflammation. Healthy GRdim/dim mice with reduced dimerization propensity due to a point mutation (A465T) at the dimer interface of the GR DNA-binding domain (DBD) (here GRD/D) have previously helped t...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2022-02, Vol.298 (2), p.101574-101574, Article 101574
Hauptverfasser:	Timmermans, Steven, Verhoog, Nicolette J.D., Van Looveren, Kelly, Dewaele, Sylviane, Hochepied, Tino, Eggermont, Melanie, Gilbert, Barbara, Boerema-de Munck, Anne, Vanderhaeghen, Tineke, Vanden Berghe, Joke, Garcia Gonzalez, Natalia, Vandewalle, Jolien, Bloch, Yehudi, Provost, Mathias, Savvides, Savvas N., De Bosscher, Karolien, Declercq, Wim, Rottier, Robbert J., Louw, Ann, Libert, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	A465T Animals Dexamethasone - pharmacology dimerization glucocorticoid receptor Glucocorticoids - pharmacology I634A ligand binding Ligands Mice mutational study Point Mutation Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!