Salmonella enterica serovar Typhimurium uses anaerobic respiration to overcome propionate-mediated colonization resistance

The gut microbiota benefits the host by limiting enteric pathogen expansion (colonization resistance), partially via the production of inhibitory metabolites. Propionate, a short-chain fatty acid produced by microbiota members, is proposed to mediate colonization resistance against Salmonella enteri...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-01, Vol.38 (1), p.110180-110180, Article 110180
Hauptverfasser:	Shelton, Catherine D, Yoo, Woongjae, Shealy, Nicolas G, Torres, Teresa P, Zieba, Jacob K, Calcutt, M Wade, Foegeding, Nora J, Kim, Dajeong, Kim, Jinshil, Ryu, Sangryeol, Byndloss, Mariana X
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobiosis - physiology Animals Antibiosis - physiology Bacteroides thetaiotaomicron - genetics Bacteroides thetaiotaomicron - metabolism Female Gastrointestinal Microbiome - physiology Germ-Free Life Intestines - microbiology Male Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Knockout Nitrates - metabolism Propionates - metabolism Salmonella Infections, Animal - pathology Salmonella typhimurium - growth & development Salmonella typhimurium - metabolism
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