Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise
Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the de...
Gespeichert in:
| Veröffentlicht in: | Cell 2020-06, Vol.181 (7), p.1464-1474 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1474 |
|---|---|
| container_issue | 7 |
| container_start_page | 1464 |
| container_title | Cell |
| container_volume | 181 |
| creator | Adkins, Joshua N. Dasari, Surendra Drugan, Jonelle K. Radom-Aizik, Shlomit Snyder, Michael P. Walsh, Martin J. Adkins, Joshua N. Amar, David Evans, Charles R. Li, Yafeng Radom-Aizik, Shlomit Sanford, James A. Schenk, Simon Lee Alekel, D. Boyce, Amanda T. Fleg, Jerome L. McGowan, Joan A. Nierras, Concepcion Pai, Vinay Peterson, Charlotte Ramos, Ed Roary, Mary C. Xia, Ashley Rooney, Jessica Miller, Michael E. Ambrosius, Walter T. Jack Rejeski, W. Lu, Ching-ju Raue, Ulrika Lester, Bridget Bergman, Bryan C. Bessesen, David H. Jankowski, Catherine M. Moreau, Kerrie L. Schauer, Irene E. Huffman, Kim M. Johnson, Johanna L. Kelly, Leslie Broskey, Nick Goodpaster, Bret H. Sparks, Lauren M. Cooper, Dan M. Haddad, Fadia Rankinen, Tuomo Ravussin, Eric Johannsen, Neil Harris, Melissa Jakicic, John M. Newman, Anne B. Forman, Daniel D. Rogers, Renee J. Page, Lindsay C. Rasmussen, Blake B. Musi, Nicolas Patel, Darpan Gelfond, Jonathan Burns, Aisling Bamman, Marcas M. Buford, Thomas W. Bodine, Sue C. Hirshman, Michael F. Albertson, Brent G. Qian, Wei-Jun Piehowski, Paul Gritsenko, Marina A. Hansen, Joshua N. Carr, Steve Jean-Beltran, Pierre M. Keshishian, Hasmik Krug, Karsten Pearce, Cadence Ivanova, Anna A. Ortlund, Eric A. Sealfon, Stuart C. Zaslavsky, Elena Nair, Venugopalan Li, SiDe Sun, Yifei Pincas, Nhanna Seenarine, Nitish Lappalainen, Tuuli Sreekumaran Nair, K. Gay, Nicole R. Zebarjadi, Navid Burant, Charles F. Li, Jun Z. Kachman, Maureen Raskind, Alexander B. Gerszten, Robert Robbins, Jeremy Newgard, Christopher B. Jimenez-Morales, David Raja, Archana Zhen, Jimmy Suk Kim, Young Christle, Jeffrey W. Marwaha, Shruti Hershman, Steven G. Hastie, Trevor Tibshirani, Robert |
| description | Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
The Molecular Transducers of Physical Activity Consortium aims to create a comprehensive, integrative multi-omic map of the effects of exercise across tissues in rodents and healthy people. |
| doi_str_mv | 10.1016/j.cell.2020.06.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8800485</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0092867420306917</els_id><sourcerecordid>2418128868</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-bc93f083cf45c8a2b79af00cbd656df417ce02c60b3203b64f8c3a5d52b769d33</originalsourceid><addsrcrecordid>eNp9kU-P0zAQxS0EYsvCF-CAfFwOCRMnThyEkKqy_JG2YoXK2XImk62rJO7aSUW_Pa66rODCaQ7-vTfj9xh7nUGaQVa-26VIfZ8KEJBCmQIUT9gig7pKiqwST9kCoBaJKqvigr0IYQcASkr5nF3kQqq6ltWC7dauJ5x74_nGmzG0M5IP3HX8dnsMFk3PlzjZg52OfOXG4Pxk54Ffrd3G3y5Xb9_ztdnv7XjHpy3xT8fRDBb5Dwr7CFPgk-PXv8ijDfSSPetMH-jVw7xkPz9fb1Zfk5vvX76tljcJygqmpME670Dl2BUSlRFNVZsOAJu2lGXbxa8hgcASmlxA3pRFpzA3spWRLOs2zy_Zx7Pvfm4GapHGyZte770djD9qZ6z-92W0W33nDlqpGKGS0eDqwcC7-5nCpAcbTlGbkdwctCgylQmlShVRcUbRuxA8dY9rMtCnkvROn5T6VJKGUscNUfTm7wMfJX9aicCHM0AxpoMlrwNaGpFa6wkn3Tr7P__fcCWlQg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2418128868</pqid></control><display><type>article</type><title>Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Adkins, Joshua N. ; Dasari, Surendra ; Drugan, Jonelle K. ; Radom-Aizik, Shlomit ; Snyder, Michael P. ; Walsh, Martin J. ; Adkins, Joshua N. ; Amar, David ; Evans, Charles R. ; Li, Yafeng ; Radom-Aizik, Shlomit ; Sanford, James A. ; Schenk, Simon ; Lee Alekel, D. ; Boyce, Amanda T. ; Fleg, Jerome L. ; McGowan, Joan A. ; Nierras, Concepcion ; Pai, Vinay ; Peterson, Charlotte ; Ramos, Ed ; Roary, Mary C. ; Xia, Ashley ; Rooney, Jessica ; Miller, Michael E. ; Ambrosius, Walter T. ; Jack Rejeski, W. ; Lu, Ching-ju ; Raue, Ulrika ; Lester, Bridget ; Bergman, Bryan C. ; Bessesen, David H. ; Jankowski, Catherine M. ; Moreau, Kerrie L. ; Schauer, Irene E. ; Huffman, Kim M. ; Johnson, Johanna L. ; Kelly, Leslie ; Broskey, Nick ; Goodpaster, Bret H. ; Sparks, Lauren M. ; Cooper, Dan M. ; Haddad, Fadia ; Rankinen, Tuomo ; Ravussin, Eric ; Johannsen, Neil ; Harris, Melissa ; Jakicic, John M. ; Newman, Anne B. ; Forman, Daniel D. ; Rogers, Renee J. ; Page, Lindsay C. ; Rasmussen, Blake B. ; Musi, Nicolas ; Patel, Darpan ; Gelfond, Jonathan ; Burns, Aisling ; Bamman, Marcas M. ; Buford, Thomas W. ; Bodine, Sue C. ; Hirshman, Michael F. ; Albertson, Brent G. ; Qian, Wei-Jun ; Piehowski, Paul ; Gritsenko, Marina A. ; Hansen, Joshua N. ; Carr, Steve ; Jean-Beltran, Pierre M. ; Keshishian, Hasmik ; Krug, Karsten ; Pearce, Cadence ; Ivanova, Anna A. ; Ortlund, Eric A. ; Sealfon, Stuart C. ; Zaslavsky, Elena ; Nair, Venugopalan ; Li, SiDe ; Sun, Yifei ; Pincas, Nhanna ; Seenarine, Nitish ; Lappalainen, Tuuli ; Sreekumaran Nair, K. ; Gay, Nicole R. ; Zebarjadi, Navid ; Burant, Charles F. ; Li, Jun Z. ; Kachman, Maureen ; Raskind, Alexander B. ; Gerszten, Robert ; Robbins, Jeremy ; Newgard, Christopher B. ; Jimenez-Morales, David ; Raja, Archana ; Zhen, Jimmy ; Suk Kim, Young ; Christle, Jeffrey W. ; Marwaha, Shruti ; Hershman, Steven G. ; Hastie, Trevor ; Tibshirani, Robert</creator><creatorcontrib>Adkins, Joshua N. ; Dasari, Surendra ; Drugan, Jonelle K. ; Radom-Aizik, Shlomit ; Snyder, Michael P. ; Walsh, Martin J. ; Adkins, Joshua N. ; Amar, David ; Evans, Charles R. ; Li, Yafeng ; Radom-Aizik, Shlomit ; Sanford, James A. ; Schenk, Simon ; Lee Alekel, D. ; Boyce, Amanda T. ; Fleg, Jerome L. ; McGowan, Joan A. ; Nierras, Concepcion ; Pai, Vinay ; Peterson, Charlotte ; Ramos, Ed ; Roary, Mary C. ; Xia, Ashley ; Rooney, Jessica ; Miller, Michael E. ; Ambrosius, Walter T. ; Jack Rejeski, W. ; Lu, Ching-ju ; Raue, Ulrika ; Lester, Bridget ; Bergman, Bryan C. ; Bessesen, David H. ; Jankowski, Catherine M. ; Moreau, Kerrie L. ; Schauer, Irene E. ; Huffman, Kim M. ; Johnson, Johanna L. ; Kelly, Leslie ; Broskey, Nick ; Goodpaster, Bret H. ; Sparks, Lauren M. ; Cooper, Dan M. ; Haddad, Fadia ; Rankinen, Tuomo ; Ravussin, Eric ; Johannsen, Neil ; Harris, Melissa ; Jakicic, John M. ; Newman, Anne B. ; Forman, Daniel D. ; Rogers, Renee J. ; Page, Lindsay C. ; Rasmussen, Blake B. ; Musi, Nicolas ; Patel, Darpan ; Gelfond, Jonathan ; Burns, Aisling ; Bamman, Marcas M. ; Buford, Thomas W. ; Bodine, Sue C. ; Hirshman, Michael F. ; Albertson, Brent G. ; Qian, Wei-Jun ; Piehowski, Paul ; Gritsenko, Marina A. ; Hansen, Joshua N. ; Carr, Steve ; Jean-Beltran, Pierre M. ; Keshishian, Hasmik ; Krug, Karsten ; Pearce, Cadence ; Ivanova, Anna A. ; Ortlund, Eric A. ; Sealfon, Stuart C. ; Zaslavsky, Elena ; Nair, Venugopalan ; Li, SiDe ; Sun, Yifei ; Pincas, Nhanna ; Seenarine, Nitish ; Lappalainen, Tuuli ; Sreekumaran Nair, K. ; Gay, Nicole R. ; Zebarjadi, Navid ; Burant, Charles F. ; Li, Jun Z. ; Kachman, Maureen ; Raskind, Alexander B. ; Gerszten, Robert ; Robbins, Jeremy ; Newgard, Christopher B. ; Jimenez-Morales, David ; Raja, Archana ; Zhen, Jimmy ; Suk Kim, Young ; Christle, Jeffrey W. ; Marwaha, Shruti ; Hershman, Steven G. ; Hastie, Trevor ; Tibshirani, Robert ; the Molecular Transducers of Physical Activity Consortium ; Molecular Transducers of Physical Activity Consortium</creatorcontrib><description>Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
The Molecular Transducers of Physical Activity Consortium aims to create a comprehensive, integrative multi-omic map of the effects of exercise across tissues in rodents and healthy people.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2020.06.004</identifier><identifier>PMID: 32589957</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Animals ; Child ; Exercise - physiology ; Female ; Humans ; Male ; Middle Aged ; Oxygen Consumption ; Physical Endurance - physiology ; Research Design ; Young Adult</subject><ispartof>Cell, 2020-06, Vol.181 (7), p.1464-1474</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-bc93f083cf45c8a2b79af00cbd656df417ce02c60b3203b64f8c3a5d52b769d33</citedby><cites>FETCH-LOGICAL-c570t-bc93f083cf45c8a2b79af00cbd656df417ce02c60b3203b64f8c3a5d52b769d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0092867420306917$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32589957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adkins, Joshua N.</creatorcontrib><creatorcontrib>Dasari, Surendra</creatorcontrib><creatorcontrib>Drugan, Jonelle K.</creatorcontrib><creatorcontrib>Radom-Aizik, Shlomit</creatorcontrib><creatorcontrib>Snyder, Michael P.</creatorcontrib><creatorcontrib>Walsh, Martin J.</creatorcontrib><creatorcontrib>Adkins, Joshua N.</creatorcontrib><creatorcontrib>Amar, David</creatorcontrib><creatorcontrib>Evans, Charles R.</creatorcontrib><creatorcontrib>Li, Yafeng</creatorcontrib><creatorcontrib>Radom-Aizik, Shlomit</creatorcontrib><creatorcontrib>Sanford, James A.</creatorcontrib><creatorcontrib>Schenk, Simon</creatorcontrib><creatorcontrib>Lee Alekel, D.</creatorcontrib><creatorcontrib>Boyce, Amanda T.</creatorcontrib><creatorcontrib>Fleg, Jerome L.</creatorcontrib><creatorcontrib>McGowan, Joan A.</creatorcontrib><creatorcontrib>Nierras, Concepcion</creatorcontrib><creatorcontrib>Pai, Vinay</creatorcontrib><creatorcontrib>Peterson, Charlotte</creatorcontrib><creatorcontrib>Ramos, Ed</creatorcontrib><creatorcontrib>Roary, Mary C.</creatorcontrib><creatorcontrib>Xia, Ashley</creatorcontrib><creatorcontrib>Rooney, Jessica</creatorcontrib><creatorcontrib>Miller, Michael E.</creatorcontrib><creatorcontrib>Ambrosius, Walter T.</creatorcontrib><creatorcontrib>Jack Rejeski, W.</creatorcontrib><creatorcontrib>Lu, Ching-ju</creatorcontrib><creatorcontrib>Raue, Ulrika</creatorcontrib><creatorcontrib>Lester, Bridget</creatorcontrib><creatorcontrib>Bergman, Bryan C.</creatorcontrib><creatorcontrib>Bessesen, David H.</creatorcontrib><creatorcontrib>Jankowski, Catherine M.</creatorcontrib><creatorcontrib>Moreau, Kerrie L.</creatorcontrib><creatorcontrib>Schauer, Irene E.</creatorcontrib><creatorcontrib>Huffman, Kim M.</creatorcontrib><creatorcontrib>Johnson, Johanna L.</creatorcontrib><creatorcontrib>Kelly, Leslie</creatorcontrib><creatorcontrib>Broskey, Nick</creatorcontrib><creatorcontrib>Goodpaster, Bret H.</creatorcontrib><creatorcontrib>Sparks, Lauren M.</creatorcontrib><creatorcontrib>Cooper, Dan M.</creatorcontrib><creatorcontrib>Haddad, Fadia</creatorcontrib><creatorcontrib>Rankinen, Tuomo</creatorcontrib><creatorcontrib>Ravussin, Eric</creatorcontrib><creatorcontrib>Johannsen, Neil</creatorcontrib><creatorcontrib>Harris, Melissa</creatorcontrib><creatorcontrib>Jakicic, John M.</creatorcontrib><creatorcontrib>Newman, Anne B.</creatorcontrib><creatorcontrib>Forman, Daniel D.</creatorcontrib><creatorcontrib>Rogers, Renee J.</creatorcontrib><creatorcontrib>Page, Lindsay C.</creatorcontrib><creatorcontrib>Rasmussen, Blake B.</creatorcontrib><creatorcontrib>Musi, Nicolas</creatorcontrib><creatorcontrib>Patel, Darpan</creatorcontrib><creatorcontrib>Gelfond, Jonathan</creatorcontrib><creatorcontrib>Burns, Aisling</creatorcontrib><creatorcontrib>Bamman, Marcas M.</creatorcontrib><creatorcontrib>Buford, Thomas W.</creatorcontrib><creatorcontrib>Bodine, Sue C.</creatorcontrib><creatorcontrib>Hirshman, Michael F.</creatorcontrib><creatorcontrib>Albertson, Brent G.</creatorcontrib><creatorcontrib>Qian, Wei-Jun</creatorcontrib><creatorcontrib>Piehowski, Paul</creatorcontrib><creatorcontrib>Gritsenko, Marina A.</creatorcontrib><creatorcontrib>Hansen, Joshua N.</creatorcontrib><creatorcontrib>Carr, Steve</creatorcontrib><creatorcontrib>Jean-Beltran, Pierre M.</creatorcontrib><creatorcontrib>Keshishian, Hasmik</creatorcontrib><creatorcontrib>Krug, Karsten</creatorcontrib><creatorcontrib>Pearce, Cadence</creatorcontrib><creatorcontrib>Ivanova, Anna A.</creatorcontrib><creatorcontrib>Ortlund, Eric A.</creatorcontrib><creatorcontrib>Sealfon, Stuart C.</creatorcontrib><creatorcontrib>Zaslavsky, Elena</creatorcontrib><creatorcontrib>Nair, Venugopalan</creatorcontrib><creatorcontrib>Li, SiDe</creatorcontrib><creatorcontrib>Sun, Yifei</creatorcontrib><creatorcontrib>Pincas, Nhanna</creatorcontrib><creatorcontrib>Seenarine, Nitish</creatorcontrib><creatorcontrib>Lappalainen, Tuuli</creatorcontrib><creatorcontrib>Sreekumaran Nair, K.</creatorcontrib><creatorcontrib>Gay, Nicole R.</creatorcontrib><creatorcontrib>Zebarjadi, Navid</creatorcontrib><creatorcontrib>Burant, Charles F.</creatorcontrib><creatorcontrib>Li, Jun Z.</creatorcontrib><creatorcontrib>Kachman, Maureen</creatorcontrib><creatorcontrib>Raskind, Alexander B.</creatorcontrib><creatorcontrib>Gerszten, Robert</creatorcontrib><creatorcontrib>Robbins, Jeremy</creatorcontrib><creatorcontrib>Newgard, Christopher B.</creatorcontrib><creatorcontrib>Jimenez-Morales, David</creatorcontrib><creatorcontrib>Raja, Archana</creatorcontrib><creatorcontrib>Zhen, Jimmy</creatorcontrib><creatorcontrib>Suk Kim, Young</creatorcontrib><creatorcontrib>Christle, Jeffrey W.</creatorcontrib><creatorcontrib>Marwaha, Shruti</creatorcontrib><creatorcontrib>Hershman, Steven G.</creatorcontrib><creatorcontrib>Hastie, Trevor</creatorcontrib><creatorcontrib>Tibshirani, Robert</creatorcontrib><creatorcontrib>the Molecular Transducers of Physical Activity Consortium</creatorcontrib><creatorcontrib>Molecular Transducers of Physical Activity Consortium</creatorcontrib><title>Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise</title><title>Cell</title><addtitle>Cell</addtitle><description>Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
The Molecular Transducers of Physical Activity Consortium aims to create a comprehensive, integrative multi-omic map of the effects of exercise across tissues in rodents and healthy people.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Child</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen Consumption</subject><subject>Physical Endurance - physiology</subject><subject>Research Design</subject><subject>Young Adult</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-P0zAQxS0EYsvCF-CAfFwOCRMnThyEkKqy_JG2YoXK2XImk62rJO7aSUW_Pa66rODCaQ7-vTfj9xh7nUGaQVa-26VIfZ8KEJBCmQIUT9gig7pKiqwST9kCoBaJKqvigr0IYQcASkr5nF3kQqq6ltWC7dauJ5x74_nGmzG0M5IP3HX8dnsMFk3PlzjZg52OfOXG4Pxk54Ffrd3G3y5Xb9_ztdnv7XjHpy3xT8fRDBb5Dwr7CFPgk-PXv8ijDfSSPetMH-jVw7xkPz9fb1Zfk5vvX76tljcJygqmpME670Dl2BUSlRFNVZsOAJu2lGXbxa8hgcASmlxA3pRFpzA3spWRLOs2zy_Zx7Pvfm4GapHGyZte770djD9qZ6z-92W0W33nDlqpGKGS0eDqwcC7-5nCpAcbTlGbkdwctCgylQmlShVRcUbRuxA8dY9rMtCnkvROn5T6VJKGUscNUfTm7wMfJX9aicCHM0AxpoMlrwNaGpFa6wkn3Tr7P__fcCWlQg</recordid><startdate>20200625</startdate><enddate>20200625</enddate><creator>Adkins, Joshua N.</creator><creator>Dasari, Surendra</creator><creator>Drugan, Jonelle K.</creator><creator>Radom-Aizik, Shlomit</creator><creator>Snyder, Michael P.</creator><creator>Walsh, Martin J.</creator><creator>Adkins, Joshua N.</creator><creator>Amar, David</creator><creator>Evans, Charles R.</creator><creator>Li, Yafeng</creator><creator>Radom-Aizik, Shlomit</creator><creator>Sanford, James A.</creator><creator>Schenk, Simon</creator><creator>Lee Alekel, D.</creator><creator>Boyce, Amanda T.</creator><creator>Fleg, Jerome L.</creator><creator>McGowan, Joan A.</creator><creator>Nierras, Concepcion</creator><creator>Pai, Vinay</creator><creator>Peterson, Charlotte</creator><creator>Ramos, Ed</creator><creator>Roary, Mary C.</creator><creator>Xia, Ashley</creator><creator>Rooney, Jessica</creator><creator>Miller, Michael E.</creator><creator>Ambrosius, Walter T.</creator><creator>Jack Rejeski, W.</creator><creator>Lu, Ching-ju</creator><creator>Raue, Ulrika</creator><creator>Lester, Bridget</creator><creator>Bergman, Bryan C.</creator><creator>Bessesen, David H.</creator><creator>Jankowski, Catherine M.</creator><creator>Moreau, Kerrie L.</creator><creator>Schauer, Irene E.</creator><creator>Huffman, Kim M.</creator><creator>Johnson, Johanna L.</creator><creator>Kelly, Leslie</creator><creator>Broskey, Nick</creator><creator>Goodpaster, Bret H.</creator><creator>Sparks, Lauren M.</creator><creator>Cooper, Dan M.</creator><creator>Haddad, Fadia</creator><creator>Rankinen, Tuomo</creator><creator>Ravussin, Eric</creator><creator>Johannsen, Neil</creator><creator>Harris, Melissa</creator><creator>Jakicic, John M.</creator><creator>Newman, Anne B.</creator><creator>Forman, Daniel D.</creator><creator>Rogers, Renee J.</creator><creator>Page, Lindsay C.</creator><creator>Rasmussen, Blake B.</creator><creator>Musi, Nicolas</creator><creator>Patel, Darpan</creator><creator>Gelfond, Jonathan</creator><creator>Burns, Aisling</creator><creator>Bamman, Marcas M.</creator><creator>Buford, Thomas W.</creator><creator>Bodine, Sue C.</creator><creator>Hirshman, Michael F.</creator><creator>Albertson, Brent G.</creator><creator>Qian, Wei-Jun</creator><creator>Piehowski, Paul</creator><creator>Gritsenko, Marina A.</creator><creator>Hansen, Joshua N.</creator><creator>Carr, Steve</creator><creator>Jean-Beltran, Pierre M.</creator><creator>Keshishian, Hasmik</creator><creator>Krug, Karsten</creator><creator>Pearce, Cadence</creator><creator>Ivanova, Anna A.</creator><creator>Ortlund, Eric A.</creator><creator>Sealfon, Stuart C.</creator><creator>Zaslavsky, Elena</creator><creator>Nair, Venugopalan</creator><creator>Li, SiDe</creator><creator>Sun, Yifei</creator><creator>Pincas, Nhanna</creator><creator>Seenarine, Nitish</creator><creator>Lappalainen, Tuuli</creator><creator>Sreekumaran Nair, K.</creator><creator>Gay, Nicole R.</creator><creator>Zebarjadi, Navid</creator><creator>Burant, Charles F.</creator><creator>Li, Jun Z.</creator><creator>Kachman, Maureen</creator><creator>Raskind, Alexander B.</creator><creator>Gerszten, Robert</creator><creator>Robbins, Jeremy</creator><creator>Newgard, Christopher B.</creator><creator>Jimenez-Morales, David</creator><creator>Raja, Archana</creator><creator>Zhen, Jimmy</creator><creator>Suk Kim, Young</creator><creator>Christle, Jeffrey W.</creator><creator>Marwaha, Shruti</creator><creator>Hershman, Steven G.</creator><creator>Hastie, Trevor</creator><creator>Tibshirani, Robert</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200625</creationdate><title>Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise</title><author>Adkins, Joshua N. ; Dasari, Surendra ; Drugan, Jonelle K. ; Radom-Aizik, Shlomit ; Snyder, Michael P. ; Walsh, Martin J. ; Adkins, Joshua N. ; Amar, David ; Evans, Charles R. ; Li, Yafeng ; Radom-Aizik, Shlomit ; Sanford, James A. ; Schenk, Simon ; Lee Alekel, D. ; Boyce, Amanda T. ; Fleg, Jerome L. ; McGowan, Joan A. ; Nierras, Concepcion ; Pai, Vinay ; Peterson, Charlotte ; Ramos, Ed ; Roary, Mary C. ; Xia, Ashley ; Rooney, Jessica ; Miller, Michael E. ; Ambrosius, Walter T. ; Jack Rejeski, W. ; Lu, Ching-ju ; Raue, Ulrika ; Lester, Bridget ; Bergman, Bryan C. ; Bessesen, David H. ; Jankowski, Catherine M. ; Moreau, Kerrie L. ; Schauer, Irene E. ; Huffman, Kim M. ; Johnson, Johanna L. ; Kelly, Leslie ; Broskey, Nick ; Goodpaster, Bret H. ; Sparks, Lauren M. ; Cooper, Dan M. ; Haddad, Fadia ; Rankinen, Tuomo ; Ravussin, Eric ; Johannsen, Neil ; Harris, Melissa ; Jakicic, John M. ; Newman, Anne B. ; Forman, Daniel D. ; Rogers, Renee J. ; Page, Lindsay C. ; Rasmussen, Blake B. ; Musi, Nicolas ; Patel, Darpan ; Gelfond, Jonathan ; Burns, Aisling ; Bamman, Marcas M. ; Buford, Thomas W. ; Bodine, Sue C. ; Hirshman, Michael F. ; Albertson, Brent G. ; Qian, Wei-Jun ; Piehowski, Paul ; Gritsenko, Marina A. ; Hansen, Joshua N. ; Carr, Steve ; Jean-Beltran, Pierre M. ; Keshishian, Hasmik ; Krug, Karsten ; Pearce, Cadence ; Ivanova, Anna A. ; Ortlund, Eric A. ; Sealfon, Stuart C. ; Zaslavsky, Elena ; Nair, Venugopalan ; Li, SiDe ; Sun, Yifei ; Pincas, Nhanna ; Seenarine, Nitish ; Lappalainen, Tuuli ; Sreekumaran Nair, K. ; Gay, Nicole R. ; Zebarjadi, Navid ; Burant, Charles F. ; Li, Jun Z. ; Kachman, Maureen ; Raskind, Alexander B. ; Gerszten, Robert ; Robbins, Jeremy ; Newgard, Christopher B. ; Jimenez-Morales, David ; Raja, Archana ; Zhen, Jimmy ; Suk Kim, Young ; Christle, Jeffrey W. ; Marwaha, Shruti ; Hershman, Steven G. ; Hastie, Trevor ; Tibshirani, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-bc93f083cf45c8a2b79af00cbd656df417ce02c60b3203b64f8c3a5d52b769d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Child</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen Consumption</topic><topic>Physical Endurance - physiology</topic><topic>Research Design</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adkins, Joshua N.</creatorcontrib><creatorcontrib>Dasari, Surendra</creatorcontrib><creatorcontrib>Drugan, Jonelle K.</creatorcontrib><creatorcontrib>Radom-Aizik, Shlomit</creatorcontrib><creatorcontrib>Snyder, Michael P.</creatorcontrib><creatorcontrib>Walsh, Martin J.</creatorcontrib><creatorcontrib>Adkins, Joshua N.</creatorcontrib><creatorcontrib>Amar, David</creatorcontrib><creatorcontrib>Evans, Charles R.</creatorcontrib><creatorcontrib>Li, Yafeng</creatorcontrib><creatorcontrib>Radom-Aizik, Shlomit</creatorcontrib><creatorcontrib>Sanford, James A.</creatorcontrib><creatorcontrib>Schenk, Simon</creatorcontrib><creatorcontrib>Lee Alekel, D.</creatorcontrib><creatorcontrib>Boyce, Amanda T.</creatorcontrib><creatorcontrib>Fleg, Jerome L.</creatorcontrib><creatorcontrib>McGowan, Joan A.</creatorcontrib><creatorcontrib>Nierras, Concepcion</creatorcontrib><creatorcontrib>Pai, Vinay</creatorcontrib><creatorcontrib>Peterson, Charlotte</creatorcontrib><creatorcontrib>Ramos, Ed</creatorcontrib><creatorcontrib>Roary, Mary C.</creatorcontrib><creatorcontrib>Xia, Ashley</creatorcontrib><creatorcontrib>Rooney, Jessica</creatorcontrib><creatorcontrib>Miller, Michael E.</creatorcontrib><creatorcontrib>Ambrosius, Walter T.</creatorcontrib><creatorcontrib>Jack Rejeski, W.</creatorcontrib><creatorcontrib>Lu, Ching-ju</creatorcontrib><creatorcontrib>Raue, Ulrika</creatorcontrib><creatorcontrib>Lester, Bridget</creatorcontrib><creatorcontrib>Bergman, Bryan C.</creatorcontrib><creatorcontrib>Bessesen, David H.</creatorcontrib><creatorcontrib>Jankowski, Catherine M.</creatorcontrib><creatorcontrib>Moreau, Kerrie L.</creatorcontrib><creatorcontrib>Schauer, Irene E.</creatorcontrib><creatorcontrib>Huffman, Kim M.</creatorcontrib><creatorcontrib>Johnson, Johanna L.</creatorcontrib><creatorcontrib>Kelly, Leslie</creatorcontrib><creatorcontrib>Broskey, Nick</creatorcontrib><creatorcontrib>Goodpaster, Bret H.</creatorcontrib><creatorcontrib>Sparks, Lauren M.</creatorcontrib><creatorcontrib>Cooper, Dan M.</creatorcontrib><creatorcontrib>Haddad, Fadia</creatorcontrib><creatorcontrib>Rankinen, Tuomo</creatorcontrib><creatorcontrib>Ravussin, Eric</creatorcontrib><creatorcontrib>Johannsen, Neil</creatorcontrib><creatorcontrib>Harris, Melissa</creatorcontrib><creatorcontrib>Jakicic, John M.</creatorcontrib><creatorcontrib>Newman, Anne B.</creatorcontrib><creatorcontrib>Forman, Daniel D.</creatorcontrib><creatorcontrib>Rogers, Renee J.</creatorcontrib><creatorcontrib>Page, Lindsay C.</creatorcontrib><creatorcontrib>Rasmussen, Blake B.</creatorcontrib><creatorcontrib>Musi, Nicolas</creatorcontrib><creatorcontrib>Patel, Darpan</creatorcontrib><creatorcontrib>Gelfond, Jonathan</creatorcontrib><creatorcontrib>Burns, Aisling</creatorcontrib><creatorcontrib>Bamman, Marcas M.</creatorcontrib><creatorcontrib>Buford, Thomas W.</creatorcontrib><creatorcontrib>Bodine, Sue C.</creatorcontrib><creatorcontrib>Hirshman, Michael F.</creatorcontrib><creatorcontrib>Albertson, Brent G.</creatorcontrib><creatorcontrib>Qian, Wei-Jun</creatorcontrib><creatorcontrib>Piehowski, Paul</creatorcontrib><creatorcontrib>Gritsenko, Marina A.</creatorcontrib><creatorcontrib>Hansen, Joshua N.</creatorcontrib><creatorcontrib>Carr, Steve</creatorcontrib><creatorcontrib>Jean-Beltran, Pierre M.</creatorcontrib><creatorcontrib>Keshishian, Hasmik</creatorcontrib><creatorcontrib>Krug, Karsten</creatorcontrib><creatorcontrib>Pearce, Cadence</creatorcontrib><creatorcontrib>Ivanova, Anna A.</creatorcontrib><creatorcontrib>Ortlund, Eric A.</creatorcontrib><creatorcontrib>Sealfon, Stuart C.</creatorcontrib><creatorcontrib>Zaslavsky, Elena</creatorcontrib><creatorcontrib>Nair, Venugopalan</creatorcontrib><creatorcontrib>Li, SiDe</creatorcontrib><creatorcontrib>Sun, Yifei</creatorcontrib><creatorcontrib>Pincas, Nhanna</creatorcontrib><creatorcontrib>Seenarine, Nitish</creatorcontrib><creatorcontrib>Lappalainen, Tuuli</creatorcontrib><creatorcontrib>Sreekumaran Nair, K.</creatorcontrib><creatorcontrib>Gay, Nicole R.</creatorcontrib><creatorcontrib>Zebarjadi, Navid</creatorcontrib><creatorcontrib>Burant, Charles F.</creatorcontrib><creatorcontrib>Li, Jun Z.</creatorcontrib><creatorcontrib>Kachman, Maureen</creatorcontrib><creatorcontrib>Raskind, Alexander B.</creatorcontrib><creatorcontrib>Gerszten, Robert</creatorcontrib><creatorcontrib>Robbins, Jeremy</creatorcontrib><creatorcontrib>Newgard, Christopher B.</creatorcontrib><creatorcontrib>Jimenez-Morales, David</creatorcontrib><creatorcontrib>Raja, Archana</creatorcontrib><creatorcontrib>Zhen, Jimmy</creatorcontrib><creatorcontrib>Suk Kim, Young</creatorcontrib><creatorcontrib>Christle, Jeffrey W.</creatorcontrib><creatorcontrib>Marwaha, Shruti</creatorcontrib><creatorcontrib>Hershman, Steven G.</creatorcontrib><creatorcontrib>Hastie, Trevor</creatorcontrib><creatorcontrib>Tibshirani, Robert</creatorcontrib><creatorcontrib>the Molecular Transducers of Physical Activity Consortium</creatorcontrib><creatorcontrib>Molecular Transducers of Physical Activity Consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adkins, Joshua N.</au><au>Dasari, Surendra</au><au>Drugan, Jonelle K.</au><au>Radom-Aizik, Shlomit</au><au>Snyder, Michael P.</au><au>Walsh, Martin J.</au><au>Adkins, Joshua N.</au><au>Amar, David</au><au>Evans, Charles R.</au><au>Li, Yafeng</au><au>Radom-Aizik, Shlomit</au><au>Sanford, James A.</au><au>Schenk, Simon</au><au>Lee Alekel, D.</au><au>Boyce, Amanda T.</au><au>Fleg, Jerome L.</au><au>McGowan, Joan A.</au><au>Nierras, Concepcion</au><au>Pai, Vinay</au><au>Peterson, Charlotte</au><au>Ramos, Ed</au><au>Roary, Mary C.</au><au>Xia, Ashley</au><au>Rooney, Jessica</au><au>Miller, Michael E.</au><au>Ambrosius, Walter T.</au><au>Jack Rejeski, W.</au><au>Lu, Ching-ju</au><au>Raue, Ulrika</au><au>Lester, Bridget</au><au>Bergman, Bryan C.</au><au>Bessesen, David H.</au><au>Jankowski, Catherine M.</au><au>Moreau, Kerrie L.</au><au>Schauer, Irene E.</au><au>Huffman, Kim M.</au><au>Johnson, Johanna L.</au><au>Kelly, Leslie</au><au>Broskey, Nick</au><au>Goodpaster, Bret H.</au><au>Sparks, Lauren M.</au><au>Cooper, Dan M.</au><au>Haddad, Fadia</au><au>Rankinen, Tuomo</au><au>Ravussin, Eric</au><au>Johannsen, Neil</au><au>Harris, Melissa</au><au>Jakicic, John M.</au><au>Newman, Anne B.</au><au>Forman, Daniel D.</au><au>Rogers, Renee J.</au><au>Page, Lindsay C.</au><au>Rasmussen, Blake B.</au><au>Musi, Nicolas</au><au>Patel, Darpan</au><au>Gelfond, Jonathan</au><au>Burns, Aisling</au><au>Bamman, Marcas M.</au><au>Buford, Thomas W.</au><au>Bodine, Sue C.</au><au>Hirshman, Michael F.</au><au>Albertson, Brent G.</au><au>Qian, Wei-Jun</au><au>Piehowski, Paul</au><au>Gritsenko, Marina A.</au><au>Hansen, Joshua N.</au><au>Carr, Steve</au><au>Jean-Beltran, Pierre M.</au><au>Keshishian, Hasmik</au><au>Krug, Karsten</au><au>Pearce, Cadence</au><au>Ivanova, Anna A.</au><au>Ortlund, Eric A.</au><au>Sealfon, Stuart C.</au><au>Zaslavsky, Elena</au><au>Nair, Venugopalan</au><au>Li, SiDe</au><au>Sun, Yifei</au><au>Pincas, Nhanna</au><au>Seenarine, Nitish</au><au>Lappalainen, Tuuli</au><au>Sreekumaran Nair, K.</au><au>Gay, Nicole R.</au><au>Zebarjadi, Navid</au><au>Burant, Charles F.</au><au>Li, Jun Z.</au><au>Kachman, Maureen</au><au>Raskind, Alexander B.</au><au>Gerszten, Robert</au><au>Robbins, Jeremy</au><au>Newgard, Christopher B.</au><au>Jimenez-Morales, David</au><au>Raja, Archana</au><au>Zhen, Jimmy</au><au>Suk Kim, Young</au><au>Christle, Jeffrey W.</au><au>Marwaha, Shruti</au><au>Hershman, Steven G.</au><au>Hastie, Trevor</au><au>Tibshirani, Robert</au><aucorp>the Molecular Transducers of Physical Activity Consortium</aucorp><aucorp>Molecular Transducers of Physical Activity Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2020-06-25</date><risdate>2020</risdate><volume>181</volume><issue>7</issue><spage>1464</spage><epage>1474</epage><pages>1464-1474</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
The Molecular Transducers of Physical Activity Consortium aims to create a comprehensive, integrative multi-omic map of the effects of exercise across tissues in rodents and healthy people.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32589957</pmid><doi>10.1016/j.cell.2020.06.004</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0092-8674 |
| ispartof | Cell, 2020-06, Vol.181 (7), p.1464-1474 |
| issn | 0092-8674 1097-4172 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8800485 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Animals Child Exercise - physiology Female Humans Male Middle Aged Oxygen Consumption Physical Endurance - physiology Research Design Young Adult |
| title | Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T15%3A44%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20Transducers%20of%20Physical%20Activity%20Consortium%20(MoTrPAC):%20Mapping%20the%20Dynamic%20Responses%20to%20Exercise&rft.jtitle=Cell&rft.au=Adkins,%20Joshua%20N.&rft.aucorp=the%20Molecular%20Transducers%20of%20Physical%20Activity%20Consortium&rft.date=2020-06-25&rft.volume=181&rft.issue=7&rft.spage=1464&rft.epage=1474&rft.pages=1464-1474&rft.issn=0092-8674&rft.eissn=1097-4172&rft_id=info:doi/10.1016/j.cell.2020.06.004&rft_dat=%3Cproquest_pubme%3E2418128868%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2418128868&rft_id=info:pmid/32589957&rft_els_id=S0092867420306917&rfr_iscdi=true |