Effects of a combined treatment regimen consisting of Hsp90 inhibitor DS-2248 and radiation in vitro and in a tumor mouse model

Heat shock protein 90 (HSP90) is a molecular chaperone that is responsible for the conformational maintenance of several client proteins that play important roles in DNA damage repair, apoptosis following radiation, and resistance to radiation therapy. DS-2248 (tricyclic pyrazolopyrimidine derivativ...

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Veröffentlicht in:	Translational cancer research 2021-06, Vol.10 (6), p.2767-2776
Hauptverfasser:	Kondo, Takuhito, Shibamoto, Yuta, Kawai, Tatsuya, Sugie, Chikao, Wang, Zhen, Nakamura, Koichi, Murai, Taro, Manabe, Yoshihiko, Nakashima, Masahiro, Matsuo, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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