Translational control of E2f1 regulates the Drosophila cell cycle

E2F transcription factors are master regulators of the eukaryotic cell cycle. In , the sole activating E2F, E2F1, is both required for and sufficient to promote G1→S progression. E2F1 activity is regulated both by binding to RB Family repressors and by posttranscriptional control of E2F1 protein lev...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-01, Vol.119 (4), p.1
Hauptverfasser:	Øvrebø, Jan Inge, Bradley-Gill, Mary-Rose, Zielke, Norman, Kim, Minhee, Marchetti, Marco, Bohlen, Jonathan, Lewis, Megan, van Straaten, Monique, Moon, Nam-Sung, Edgar, Bruce A
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Animals Biological Sciences Biomarkers Cell cycle Cell Cycle - genetics Cell growth Cell Proliferation Drosophila Drosophila - genetics Drosophila - metabolism Drosophila Proteins - metabolism E2F1 protein Epidermal growth factor receptors Fluorescent Antibody Technique Fruit flies Gene Expression Regulation Insects Kinases Mitosis Open Reading Frames Post-transcription Protein Biosynthesis Regulatory sequences Repressors RNA Processing, Post-Transcriptional Signaling Stem cells Stress, Physiological - genetics Transcription factors Transcription Factors - metabolism Transgenes Translation Untranslated Regions Wings, Animal - metabolism
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