Noncanonical function of the Sexlethal gene controls the protogyny phenotype in Drosophila melanogaster
Drosophila melanogaster females eclose on average 4 h faster than males owing to sexual differences in the pupal period, referred to as the protogyny phenotype. Here, to elucidate the mechanism underlying the protogyny phenotype, we used our newly developed Drosophila Individual Activity Monitoring...
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| description | Drosophila melanogaster
females eclose on average 4 h faster than males owing to sexual differences in the pupal period, referred to as the protogyny phenotype. Here, to elucidate the mechanism underlying the protogyny phenotype, we used our newly developed
Drosophila
Individual Activity Monitoring and Detecting System (DIAMonDS) that detects the precise timing of both pupariation and eclosion in individual flies. Although sex transformation induced by
tra-2
,
tra
alteration, or
msl-2
knockdown-mediated disruption of dosage compensation showed no effect on the protogyny phenotype, stage-specific whole-body knockdown and mutation of the
Drosophila
master sex switch gene,
Sxl
, was found to disrupt the protogyny phenotype. Thus,
Sxl
establishes the protogyny phenotype through a noncanonical pathway in
D. melanogaster. |
| doi_str_mv | 10.1038/s41598-022-05147-5 |
| format | Article |
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females eclose on average 4 h faster than males owing to sexual differences in the pupal period, referred to as the protogyny phenotype. Here, to elucidate the mechanism underlying the protogyny phenotype, we used our newly developed
Drosophila
Individual Activity Monitoring and Detecting System (DIAMonDS) that detects the precise timing of both pupariation and eclosion in individual flies. Although sex transformation induced by
tra-2
,
tra
alteration, or
msl-2
knockdown-mediated disruption of dosage compensation showed no effect on the protogyny phenotype, stage-specific whole-body knockdown and mutation of the
Drosophila
master sex switch gene,
Sxl
, was found to disrupt the protogyny phenotype. Thus,
Sxl
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females eclose on average 4 h faster than males owing to sexual differences in the pupal period, referred to as the protogyny phenotype. Here, to elucidate the mechanism underlying the protogyny phenotype, we used our newly developed
Drosophila
Individual Activity Monitoring and Detecting System (DIAMonDS) that detects the precise timing of both pupariation and eclosion in individual flies. Although sex transformation induced by
tra-2
,
tra
alteration, or
msl-2
knockdown-mediated disruption of dosage compensation showed no effect on the protogyny phenotype, stage-specific whole-body knockdown and mutation of the
Drosophila
master sex switch gene,
Sxl
, was found to disrupt the protogyny phenotype. Thus,
Sxl
establishes the protogyny phenotype through a noncanonical pathway in
D. melanogaster.</description><subject>631/136</subject><subject>631/208</subject><subject>Dosage compensation</subject><subject>Drosophila</subject><subject>Drosophila melanogaster</subject><subject>Eclosion</subject><subject>Genotype & phenotype</subject><subject>Humanities and Social Sciences</subject><subject>Insects</subject><subject>multidisciplinary</subject><subject>Phenotypes</subject><subject>Pupariation</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpVkUtLBDEQhIMguqh_wFPA82gnmcxMLoKsTxA9qOeQnel5yGwyJllx_73ZB4h96UNVfxRdhJwzuGQgqquQM6mqDDjPQLK8zOQBmXHIZcYF58fkLIRPSCO5ypk6IsdCQlWm0xnpXpytjXV2qM1I25Wt4-AsdS2NPdI3_Bkx9knp0CKtnY3ejWGrTd5F163tmk49WhfXE9LB0lvvgpv6YTR0iWMidyZE9KfksDVjwLP9PiEf93fv88fs-fXhaX7znE2c8ZgJYABctqJpRa6KEpumWpjGsKKsFZSwUCiaihWy4AUIIVReVAtRCYMGy9yAOCHXO-60WiyxqTElNqOe_LA0fq2dGfR_xQ697ty3rkolOdsALvYA775WGKL-dCtvU2bNi_RO4KBEcomdKySy7dD_uRjoTSl6V4pOpehtKVqKX7ykgiE</recordid><startdate>20220127</startdate><enddate>20220127</enddate><creator>Seong, Ki-Hyeon</creator><creator>Kang, Siu</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20220127</creationdate><title>Noncanonical function of the Sexlethal gene controls the protogyny phenotype in Drosophila melanogaster</title><author>Seong, Ki-Hyeon ; 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females eclose on average 4 h faster than males owing to sexual differences in the pupal period, referred to as the protogyny phenotype. Here, to elucidate the mechanism underlying the protogyny phenotype, we used our newly developed
Drosophila
Individual Activity Monitoring and Detecting System (DIAMonDS) that detects the precise timing of both pupariation and eclosion in individual flies. Although sex transformation induced by
tra-2
,
tra
alteration, or
msl-2
knockdown-mediated disruption of dosage compensation showed no effect on the protogyny phenotype, stage-specific whole-body knockdown and mutation of the
Drosophila
master sex switch gene,
Sxl
, was found to disrupt the protogyny phenotype. Thus,
Sxl
establishes the protogyny phenotype through a noncanonical pathway in
D. melanogaster.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35087103</pmid><doi>10.1038/s41598-022-05147-5</doi><oa>free_for_read</oa></addata></record> |
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| source | Nature Open Access; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 631/136 631/208 Dosage compensation Drosophila Drosophila melanogaster Eclosion Genotype & phenotype Humanities and Social Sciences Insects multidisciplinary Phenotypes Pupariation Science Science (multidisciplinary) |
| title | Noncanonical function of the Sexlethal gene controls the protogyny phenotype in Drosophila melanogaster |
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