Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome

Background Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene. The pathophysiology of neurological manifestations is still unclear, but neuronal hyperexci...

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Veröffentlicht in:	Journal of neurology 2022-06, Vol.269 (6), p.3238-3248
Hauptverfasser:	Guerrero-Molina, María Paz, Morales-Conejo, Montserrat, Delmiro, Aitor, Morán, María, Domínguez-González, Cristina, Arranz-Canales, Elena, Ramos-González, Ana, Arenas, Joaquín, Martín, Miguel A., González de la Aleja, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Adult Alanine Amino acids Astrocytes Case-Control Studies Cerebrospinal fluid COVID-19 DNA, Mitochondrial - genetics Female Glucose metabolism Glutamatergic transmission Glutamic Acid - metabolism Glutamine Glutamine - metabolism Humans Lactic Acid Lactic acidosis Male Medicine Medicine & Public Health MELAS syndrome MELAS Syndrome - genetics Metabolism Middle Aged Mitochondrial DNA Neurology Neuroradiology Neurosciences Neurotransmission Original Communication Oxidation Stroke Stroke-like episodes
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