Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism

Inhibition of bacterial cell division is a novel mechanistic action in the development of new antimicrobial agents. The FtsZ protein is an important antimicrobial drug target because of its essential role in bacterial cell division. In the present study, potential inhibitors of FtsZ were identified...

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Veröffentlicht in:	MedChemComm 2022-01, Vol.13 (1), p.79-89
Hauptverfasser:	Du, Ruo-Lan, Sun, Ning, Fung, Yik-Hong, Zheng, Yuan-Yuan, Chen, Yu-Wei, Chan, Pak-Ho, Wong, Wing-Leung, Wong, Kwok-Yin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antiinfectives and antibacterials Antimicrobial agents Bioassays Cell division Chemistry Drug resistance FtsZ protein Inhibitors Screening Therapeutic targets
Online-Zugang:	Volltext
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