Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury

Acinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies was to define the populations arising from ADM, the associated transcriptional changes, and markers of disease progression. Acinar cells we...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2022-02, Vol.162 (2), p.604-620.e20
Hauptverfasser:	Ma, Zhibo, Lytle, Nikki K., Chen, Bob, Jyotsana, Nidhi, Novak, Sammy Weiser, Cho, Charles J., Caplan, Leah, Ben-Levy, Olivia, Neininger, Abigail C., Burnette, Dylan T., Trinh, Vincent Q., Tan, Marcus C.B., Patterson, Emilee A., Arrojo e Drigo, Rafael, Giraddi, Rajshekhar R., Ramos, Cynthia, Means, Anna L., Matsumoto, Ichiro, Manor, Uri, Mills, Jason C., Goldenring, James R., Lau, Ken S., Wahl, Geoffrey M., DelGiorno, Kathleen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - cytology Acinar Cells - metabolism ADM Carcinoma, Pancreatic Ductal - genetics Cell Plasticity - genetics Enteroendocrine Cells Enteroendocrine Cells - cytology Enteroendocrine Cells - metabolism Gene Expression Profiling Humans Metaplasia - genetics Metaplasia - metabolism Mucin 5AC - genetics Paligenosis Pancreas - cytology Pancreas - metabolism Pancreatic Ducts - cytology Pancreatic Ducts - metabolism Pancreatic Neoplasms - genetics Pancreatitis - genetics Pancreatitis - metabolism Plasticity Proto-Oncogene Proteins p21(ras) - genetics Single-Cell Analysis Tuft Cells
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