The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway

The excess deposition of underlying extracellular matrix (ECM) in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder such as obesity and type 2 diabetes. Anti-fibrosis therapy has received much attention in the treatment of metabolic disorders. Oro...

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Veröffentlicht in:	Acta pharmacologica Sinica 2022-02, Vol.43 (2), p.367-375
Hauptverfasser:	Wang, Peng-yuan, Feng, Jia-yi, Zhang, Zhen, Chen, Yi, Qin, Zhen, Dai, Xian-min, Wei, Jie, Hu, Bo-han, Zhang, Wei-dong, Sun, Yang, Liu, Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Acute phase proteins Adipokines - pharmacology Adipose tissue Adipose Tissue - diagnostic imaging Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose Tissue - pathology AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Biomedical and Life Sciences Biomedicine Blotting, Western Body fat Collagen Collagenase 3 Diabetes mellitus (non-insulin dependent) Diet, High-Fat - adverse effects Extracellular matrix Fibroblasts Fibrosis Gelatinase A High fat diet Immunology Internal Medicine Kinases Magnetic Resonance Imaging Male Medical Microbiology Metabolic disorders Metabolism Mice Mice, Inbred C57BL Obesity Orosomucoid - deficiency Orosomucoid - pharmacology Pharmacology/Toxicology Phenotypes Phosphorylation Signal Transduction - drug effects Tissue inhibitor of metalloproteinase 1 Tissue inhibitor of metalloproteinase 2 Tissue inhibitor of metalloproteinase 3 Transforming growth factor-b1 Vaccine
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