An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovitis and the destruction of small joints. Emerging evidence shows that immunoglobulin D (IgD) stimulation induces T-cell activation, which may contribute to diseases pathogenesis in RA. In this study, we investi...

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Veröffentlicht in:	Acta pharmacologica Sinica 2022-02, Vol.43 (2), p.387-400
Hauptverfasser:	Hu, Xiao-xi, Zhang, Ai-jun, Pan, Wen-wen, Xin, Qian-ling, Chen, Jing-yu, Zhang, Ling-ling, Chang, Yan, Wu, Yu-jing, Wei, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Animals Arthritis, Rheumatoid - drug therapy Autoimmune diseases B-Lymphocytes - drug effects Biomedical and Life Sciences Biomedicine CD19 antigen CD4 antigen CD40 antigen CD40L protein CD86 antigen Cell activation Cell proliferation Coculture Techniques Collagen Fc receptors Flow Cytometry Fusion protein Humans Immunoglobulin D Immunoglobulin D - metabolism Immunoglobulin D - therapeutic use Immunoglobulin G Immunology Internal Medicine Joint diseases Lck protein Leukocytes (mononuclear) Lymphocyte Activation - drug effects Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Lymphocytes Lymphocytes B Lymphocytes T Male Medical Microbiology Mice Mice, Inbred DBA Microscopy, Confocal NF-κB protein Nuclear transport Patients Peripheral blood mononuclear cells Pharmacology/Toxicology Proteins Receptors, Fc - therapeutic use Recombinant Proteins Rheumatoid arthritis Signal transduction Signal Transduction - drug effects T-Lymphocytes - drug effects Vaccine
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