SOSIP Trimer-Specific Antibodies Isolated from a Simian-Human Immunodeficiency Virus-Infected Monkey with versus without a Pre-blocking Step with gp41

BG505 SOSIP.664 (hereafter referred to as SOSIP), a stabilized trimeric mimic of the HIV-1 envelope spike resembling the native viral spike, is a useful tool for isolating anti-HIV-1 neutralizing antibodies. We screened long-term SHIV-AD8 infected rhesus monkeys for potency and breadth of serum neut...

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Veröffentlicht in:	Journal of virology 2022-01, Vol.96 (2), p.e0158221-e0158221
Hauptverfasser:	Duggan, Natasha N, Weisgrau, Kim L, Magnani, Diogo M, Rakasz, Eva G, Desrosiers, Ronald C, Martinez-Navio, Jose M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification Antibody Specificity Broadly Neutralizing Antibodies - genetics Broadly Neutralizing Antibodies - immunology Broadly Neutralizing Antibodies - isolation & purification env Gene Products, Human Immunodeficiency Virus - immunology HIV Antibodies - genetics HIV Antibodies - immunology HIV Antibodies - isolation & purification HIV Envelope Protein gp41 - immunology HIV-1 - immunology Immunoglobulin Variable Region - genetics Macaca mulatta Pathogenesis and Immunity Recombinant Proteins - immunology Simian Immunodeficiency Virus - immunology Virology
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