Ribosomal leaky scanning through a translated uORF requires eIF4G2

Abstract eIF4G2 (DAP5 or Nat1) is a homologue of the canonical translation initiation factor eIF4G1 in higher eukaryotes but its function remains poorly understood. Unlike eIF4G1, eIF4G2 does not interact with the cap-binding protein eIF4E and is believed to drive translation under stress when eIF4E...

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Veröffentlicht in:	Nucleic acids research 2022-01, Vol.50 (2), p.1111-1127
Hauptverfasser:	Smirnova, Victoria V, Shestakova, Ekaterina D, Nogina, Daria S, Mishchenko, Polina A, Prikazchikova, Tatiana A, Zatsepin, Timofei S, Kulakovskiy, Ivan V, Shatsky, Ivan N, Terenin, Ilya M
Format:	Artikel
Sprache:	eng
Schlagworte:	Eukaryotic Initiation Factor-4G - metabolism Humans Open Reading Frames Protein Biosynthesis Ribosomes - metabolism RNA and RNA-protein complexes RNA, Messenger - metabolism
Online-Zugang:	Volltext
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