Modeling the SARS-CoV-2 parallel transmission dynamics: Asymptomatic and symptomatic pathways
Asymptomatic transmission of the coronavirus disease and the infected individual prediction has become very important in the COVID-19 outbreak study. The asymptomatic and symptomatic transmission studies are still ongoing to assess their impacts on disease monitoring and burden. However, there has b...
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| Veröffentlicht in: | Computers in biology and medicine 2022-04, Vol.143, p.105264-105264, Article 105264 |
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| description | Asymptomatic transmission of the coronavirus disease and the infected individual prediction has become very important in the COVID-19 outbreak study. The asymptomatic and symptomatic transmission studies are still ongoing to assess their impacts on disease monitoring and burden. However, there has been limited research on how asymptomatic and symptomatic transmissions together can affect the coronavirus disease outbreak. A mathematical model is therefore needed to be developed in order to assess the effect of these transmissions on the coronavirus disease dynamics. This paper develops a mathematical model concerning asymptomatic and symptomatic disease transmission processes in the COVID-19 outbreak. The model sensitivity has been analysed in terms of the variance of each parameter, and the local stability at two equilibrium points have been discussed in terms of the basic reproduction number (R0). It is found that the disease-free equilibrium gets stable for R0 1 and unstable otherwise. The proportion of the effect of asymptomatic and symptomatic transmission rates on R0 is calculated to be approximately between 1 and 3. The results demonstrate that asymptomatic transmission has a significant impact compared to symptomatic transmission in the disease outbreak. Outcomes of this study will contribute to setting an effective control strategy for the COVID-19 outbreak.
•Asymptomatic and symptomatic disease transmission is analysed in COVID-19 outbreak.•Disease-free and endemic equilibrium gets stable for R01, respectively.•Proportion of asymptomatic and symptomatic impact rates on R0 ranges from 1 to 3 (approx.)•Asymptomatic transmission has a significant impact compared to the symptomatic one. |
| doi_str_mv | 10.1016/j.compbiomed.2022.105264 |
| format | Article |
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•Asymptomatic and symptomatic disease transmission is analysed in COVID-19 outbreak.•Disease-free and endemic equilibrium gets stable for R0<1 and R0>1, respectively.•Proportion of asymptomatic and symptomatic impact rates on R0 ranges from 1 to 3 (approx.)•Asymptomatic transmission has a significant impact compared to the symptomatic one.</description><identifier>ISSN: 0010-4825</identifier><identifier>EISSN: 1879-0534</identifier><identifier>DOI: 10.1016/j.compbiomed.2022.105264</identifier><identifier>PMID: 35182952</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Asymptomatic transmission ; Basic reproduction number ; Coronaviruses ; COVID-19 ; Disease control ; Disease transmission ; Infectious diseases ; Mathematical model ; Mathematical models ; Outbreaks ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Symptomatic transmission ; Viral diseases</subject><ispartof>Computers in biology and medicine, 2022-04, Vol.143, p.105264-105264, Article 105264</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>2022. The Authors</rights><rights>2022 Elsevier Ltd. All rights reserved. 2022 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-eff9fb414f150cf685189445d639bccec61f9b79a5d875beb5e61990b85511e83</citedby><cites>FETCH-LOGICAL-c507t-eff9fb414f150cf685189445d639bccec61f9b79a5d875beb5e61990b85511e83</cites><orcidid>0000-0003-3360-3636</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2635485442?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35182952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chowdhury, S.M.E.K.</creatorcontrib><creatorcontrib>Forkan, Mohammad</creatorcontrib><creatorcontrib>Ahmed, Shams Forruque</creatorcontrib><creatorcontrib>Agarwal, Praveen</creatorcontrib><creatorcontrib>Shawkat Ali, A.B.M.</creatorcontrib><creatorcontrib>Muyeen, S.M.</creatorcontrib><title>Modeling the SARS-CoV-2 parallel transmission dynamics: Asymptomatic and symptomatic pathways</title><title>Computers in biology and medicine</title><addtitle>Comput Biol Med</addtitle><description>Asymptomatic transmission of the coronavirus disease and the infected individual prediction has become very important in the COVID-19 outbreak study. The asymptomatic and symptomatic transmission studies are still ongoing to assess their impacts on disease monitoring and burden. However, there has been limited research on how asymptomatic and symptomatic transmissions together can affect the coronavirus disease outbreak. A mathematical model is therefore needed to be developed in order to assess the effect of these transmissions on the coronavirus disease dynamics. This paper develops a mathematical model concerning asymptomatic and symptomatic disease transmission processes in the COVID-19 outbreak. The model sensitivity has been analysed in terms of the variance of each parameter, and the local stability at two equilibrium points have been discussed in terms of the basic reproduction number (R0). It is found that the disease-free equilibrium gets stable for R0 < 1 whereas the endemic equilibrium becomes stable for R0 > 1 and unstable otherwise. The proportion of the effect of asymptomatic and symptomatic transmission rates on R0 is calculated to be approximately between 1 and 3. The results demonstrate that asymptomatic transmission has a significant impact compared to symptomatic transmission in the disease outbreak. Outcomes of this study will contribute to setting an effective control strategy for the COVID-19 outbreak.
•Asymptomatic and symptomatic disease transmission is analysed in COVID-19 outbreak.•Disease-free and endemic equilibrium gets stable for R0<1 and R0>1, respectively.•Proportion of asymptomatic and symptomatic impact rates on R0 ranges from 1 to 3 (approx.)•Asymptomatic transmission has a significant impact compared to the symptomatic one.</description><subject>Asymptomatic transmission</subject><subject>Basic reproduction number</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Disease control</subject><subject>Disease transmission</subject><subject>Infectious diseases</subject><subject>Mathematical model</subject><subject>Mathematical models</subject><subject>Outbreaks</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Symptomatic transmission</subject><subject>Viral 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parallel transmission dynamics: Asymptomatic and symptomatic pathways</atitle><jtitle>Computers in biology and medicine</jtitle><addtitle>Comput Biol Med</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>143</volume><spage>105264</spage><epage>105264</epage><pages>105264-105264</pages><artnum>105264</artnum><issn>0010-4825</issn><eissn>1879-0534</eissn><abstract>Asymptomatic transmission of the coronavirus disease and the infected individual prediction has become very important in the COVID-19 outbreak study. The asymptomatic and symptomatic transmission studies are still ongoing to assess their impacts on disease monitoring and burden. However, there has been limited research on how asymptomatic and symptomatic transmissions together can affect the coronavirus disease outbreak. A mathematical model is therefore needed to be developed in order to assess the effect of these transmissions on the coronavirus disease dynamics. This paper develops a mathematical model concerning asymptomatic and symptomatic disease transmission processes in the COVID-19 outbreak. The model sensitivity has been analysed in terms of the variance of each parameter, and the local stability at two equilibrium points have been discussed in terms of the basic reproduction number (R0). It is found that the disease-free equilibrium gets stable for R0 < 1 whereas the endemic equilibrium becomes stable for R0 > 1 and unstable otherwise. The proportion of the effect of asymptomatic and symptomatic transmission rates on R0 is calculated to be approximately between 1 and 3. The results demonstrate that asymptomatic transmission has a significant impact compared to symptomatic transmission in the disease outbreak. Outcomes of this study will contribute to setting an effective control strategy for the COVID-19 outbreak.
•Asymptomatic and symptomatic disease transmission is analysed in COVID-19 outbreak.•Disease-free and endemic equilibrium gets stable for R0<1 and R0>1, respectively.•Proportion of asymptomatic and symptomatic impact rates on R0 ranges from 1 to 3 (approx.)•Asymptomatic transmission has a significant impact compared to the symptomatic one.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>35182952</pmid><doi>10.1016/j.compbiomed.2022.105264</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3360-3636</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Asymptomatic transmission Basic reproduction number Coronaviruses COVID-19 Disease control Disease transmission Infectious diseases Mathematical model Mathematical models Outbreaks SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Symptomatic transmission Viral diseases |
| title | Modeling the SARS-CoV-2 parallel transmission dynamics: Asymptomatic and symptomatic pathways |
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