A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector functions alone can protect against SARS-CoV-2. Here, we isolated CV3-13, a non-neutralizing antibody, from a convalescen...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-02, Vol.38 (7), p.110368-110368, Article 110368
Hauptverfasser:	Beaudoin-Bussières, Guillaume, Chen, Yaozong, Ullah, Irfan, Prévost, Jérémie, Tolbert, William D., Symmes, Kelly, Ding, Shilei, Benlarbi, Mehdi, Gong, Shang Yu, Tauzin, Alexandra, Gasser, Romain, Chatterjee, Debashree, Vézina, Dani, Goyette, Guillaume, Richard, Jonathan, Zhou, Fei, Stamatatos, Leonidas, McGuire, Andrew T., Charest, Hughes, Roger, Michel, Pozharski, Edwin, Kumar, Priti, Mothes, Walther, Uchil, Pradeep D., Pazgier, Marzena, Finzi, Andrés
Format:	Artikel
Sprache:	eng
Schlagworte:	ADCC Animals Antibodies, Neutralizing - therapeutic use Antibodies, Viral - chemistry Antibodies, Viral - immunology Antibodies, Viral - therapeutic use Antibody-Dependent Cell Cytotoxicity coronavirus COVID-19 COVID-19 - mortality COVID-19 - prevention & control COVID-19 - therapy COVID-19 - transmission Disease Models, Animal Epitopes Fc-effector functions Humans Immunization, Passive - mortality Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - metabolism Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - immunology K18-hACE2 mice Mice non-neutralizing antibodies Protein Binding Protein Conformation SARS-CoV-2 SARS-CoV-2 - immunology SARS-CoV-2 - pathogenicity spike Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism synergy
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