A pilot study of multilevel analysis of BDNF in paternal and maternal perinatal depression
Depression in the perinatal period is common in mothers worldwide. Emerging research indicates that fathers are also at risk of developing perinatal depression. However, knowledge regarding biological risk factors and pathophysiological mechanisms of perinatal depression is still scarce, particularl...
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| Veröffentlicht in: | Archives of women's mental health 2022-02, Vol.25 (1), p.237-249 |
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| creator | Kittel-Schneider, Sarah Davidova, Petra Kalok, Miriam Essel, Corina Ahmed, Fadia Ben Kingeter, Yasmina Matentzoglu, Maria Leutritz, Anna Linda Kersken, Katharina Koreny, Carolin Weber, Heike Kollert, Leonie McNeill, Rhiannon V. Reif, Andreas Bahlmann, Franz Trautmann-Villalba, Patricia |
| description | Depression in the perinatal period is common in mothers worldwide. Emerging research indicates that fathers are also at risk of developing perinatal depression. However, knowledge regarding biological risk factors and pathophysiological mechanisms of perinatal depression is still scarce, particularly in fathers. It has been suggested that the neurotrophin BDNF may play a role in maternal perinatal depression; however, there is currently no data regarding paternal perinatal depression. For this pilot study, 81 expecting parents were recruited and assessed at several time points. We screened for depression using EPDS and MADRS, investigated several psychosocial variables, and took blood samples for BDNF val66met genotyping, epigenetic, and protein analysis. Between pregnancy and 12 months postpartum (pp), we found that 3.7 to 15.7% of fathers screened positive for depression, and 9.6 to 24% of mothers, with at least a twofold increased prevalence in both parents using MADRS compared with EPDS. We also identified several psychosocial factors associated with perinatal depression in both parents. The data revealed a trend that lower BDNF levels correlated with maternal depressive symptoms at 3 months pp. In the fathers, no significant correlations between BDNF and perinatal depression were found. Pregnant women demonstrated lower BDNF methylation and BDNF protein expression compared with men; however, these were found to increase postpartum. Lastly, we identified correlations between depressive symptoms and psychosocial/neurobiological factors. The data suggest that BDNF may play a role in maternal perinatal depression, but not paternal. |
| doi_str_mv | 10.1007/s00737-021-01197-2 |
| format | Article |
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Emerging research indicates that fathers are also at risk of developing perinatal depression. However, knowledge regarding biological risk factors and pathophysiological mechanisms of perinatal depression is still scarce, particularly in fathers. It has been suggested that the neurotrophin BDNF may play a role in maternal perinatal depression; however, there is currently no data regarding paternal perinatal depression. For this pilot study, 81 expecting parents were recruited and assessed at several time points. We screened for depression using EPDS and MADRS, investigated several psychosocial variables, and took blood samples for BDNF val66met genotyping, epigenetic, and protein analysis. Between pregnancy and 12 months postpartum (pp), we found that 3.7 to 15.7% of fathers screened positive for depression, and 9.6 to 24% of mothers, with at least a twofold increased prevalence in both parents using MADRS compared with EPDS. We also identified several psychosocial factors associated with perinatal depression in both parents. The data revealed a trend that lower BDNF levels correlated with maternal depressive symptoms at 3 months pp. In the fathers, no significant correlations between BDNF and perinatal depression were found. Pregnant women demonstrated lower BDNF methylation and BDNF protein expression compared with men; however, these were found to increase postpartum. Lastly, we identified correlations between depressive symptoms and psychosocial/neurobiological factors. The data suggest that BDNF may play a role in maternal perinatal depression, but not paternal.</description><identifier>ISSN: 1434-1816</identifier><identifier>EISSN: 1435-1102</identifier><identifier>DOI: 10.1007/s00737-021-01197-2</identifier><identifier>PMID: 34989854</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analysis ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Demographic aspects ; Depression - etiology ; Depression, Mental ; Depression, Postpartum - epidemiology ; Depression, Postpartum - psychology ; Diagnosis ; Epigenetics ; Fathers ; Fathers - psychology ; Female ; Genotyping ; Health aspects ; Humans ; Male ; Medicine ; Medicine & Public Health ; Mens health ; Mental depression ; Methylation ; Mothers ; Mothers - psychology ; Multilevel Analysis ; Original ; Original Article ; Pilot Projects ; Postpartum ; Postpartum depression ; Pregnancy ; Prenatal depression ; Psychiatry ; Psychological aspects ; Psychotherapy ; Risk Factors ; Womens health</subject><ispartof>Archives of women's mental health, 2022-02, Vol.25 (1), p.237-249</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-dbc4d37146779b030fa31fbee8d76b0b2999178dd178162fc5e79e380d1f982c3</citedby><cites>FETCH-LOGICAL-c572t-dbc4d37146779b030fa31fbee8d76b0b2999178dd178162fc5e79e380d1f982c3</cites><orcidid>0000-0003-3057-6150</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00737-021-01197-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00737-021-01197-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34989854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kittel-Schneider, Sarah</creatorcontrib><creatorcontrib>Davidova, Petra</creatorcontrib><creatorcontrib>Kalok, Miriam</creatorcontrib><creatorcontrib>Essel, Corina</creatorcontrib><creatorcontrib>Ahmed, Fadia Ben</creatorcontrib><creatorcontrib>Kingeter, Yasmina</creatorcontrib><creatorcontrib>Matentzoglu, Maria</creatorcontrib><creatorcontrib>Leutritz, Anna Linda</creatorcontrib><creatorcontrib>Kersken, Katharina</creatorcontrib><creatorcontrib>Koreny, Carolin</creatorcontrib><creatorcontrib>Weber, Heike</creatorcontrib><creatorcontrib>Kollert, Leonie</creatorcontrib><creatorcontrib>McNeill, Rhiannon V.</creatorcontrib><creatorcontrib>Reif, Andreas</creatorcontrib><creatorcontrib>Bahlmann, Franz</creatorcontrib><creatorcontrib>Trautmann-Villalba, Patricia</creatorcontrib><title>A pilot study of multilevel analysis of BDNF in paternal and maternal perinatal depression</title><title>Archives of women's mental health</title><addtitle>Arch Womens Ment Health</addtitle><addtitle>Arch Womens Ment Health</addtitle><description>Depression in the perinatal period is common in mothers worldwide. Emerging research indicates that fathers are also at risk of developing perinatal depression. However, knowledge regarding biological risk factors and pathophysiological mechanisms of perinatal depression is still scarce, particularly in fathers. It has been suggested that the neurotrophin BDNF may play a role in maternal perinatal depression; however, there is currently no data regarding paternal perinatal depression. For this pilot study, 81 expecting parents were recruited and assessed at several time points. We screened for depression using EPDS and MADRS, investigated several psychosocial variables, and took blood samples for BDNF val66met genotyping, epigenetic, and protein analysis. Between pregnancy and 12 months postpartum (pp), we found that 3.7 to 15.7% of fathers screened positive for depression, and 9.6 to 24% of mothers, with at least a twofold increased prevalence in both parents using MADRS compared with EPDS. We also identified several psychosocial factors associated with perinatal depression in both parents. The data revealed a trend that lower BDNF levels correlated with maternal depressive symptoms at 3 months pp. In the fathers, no significant correlations between BDNF and perinatal depression were found. Pregnant women demonstrated lower BDNF methylation and BDNF protein expression compared with men; however, these were found to increase postpartum. Lastly, we identified correlations between depressive symptoms and psychosocial/neurobiological factors. The data suggest that BDNF may play a role in maternal perinatal depression, but not paternal.</description><subject>Analysis</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Demographic aspects</subject><subject>Depression - etiology</subject><subject>Depression, Mental</subject><subject>Depression, Postpartum - epidemiology</subject><subject>Depression, Postpartum - psychology</subject><subject>Diagnosis</subject><subject>Epigenetics</subject><subject>Fathers</subject><subject>Fathers - psychology</subject><subject>Female</subject><subject>Genotyping</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mens health</subject><subject>Mental depression</subject><subject>Methylation</subject><subject>Mothers</subject><subject>Mothers - psychology</subject><subject>Multilevel Analysis</subject><subject>Original</subject><subject>Original Article</subject><subject>Pilot Projects</subject><subject>Postpartum</subject><subject>Postpartum depression</subject><subject>Pregnancy</subject><subject>Prenatal depression</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Psychotherapy</subject><subject>Risk Factors</subject><subject>Womens health</subject><issn>1434-1816</issn><issn>1435-1102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>QXPDG</sourceid><recordid>eNp9kt9v1SAUx4nRuLn5D_hgmpgYXzqB0lJeTK6bU5PFveiLL4SW03tZKFSgS-5_P7q7X9cYSwKnnM_50h6-CL0h-IRgzD_GPFW8xJSUmBDBS_oMHRJW1SUhmD6_jVlJWtIcoFcxXmGMayHYS3RQMdGKtmaH6PeqmIz1qYhp1tvCD8U422QsXIMtlFN2G01ctj-f_TgvjCsmlSDk_ZzUxXj_MkEwTqUcaZgCxGi8O0YvBmUjvL5bj9Cv8y8_T7-VF5dfv5-uLsq-5jSVuuuZrjhhDeeiwxUeVEWGDqDVvOlwR4UQhLda54k0dOhr4AKqFmsyiJb21RH6tNOd5m4E3YNLQVk5BTOqsJVeGbmfcWYj1_5atrxlTIgs8OFOIPg_M8QkRxN7sFY58HOUtCGcclHXC_ruL_TKz0sHFopSLATF9JFaKwvSuMHnc_tFVK4aQfJTM56pk39QeWgYTe8dDPka9gvePynYgLJpE72dU2523AfpDuyDjzHA8NAMguViHbmzjszWkbfWkctHv33axoeSe69koNoBMafcGsLjv_9H9gby4czs</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Kittel-Schneider, Sarah</creator><creator>Davidova, Petra</creator><creator>Kalok, Miriam</creator><creator>Essel, Corina</creator><creator>Ahmed, Fadia Ben</creator><creator>Kingeter, Yasmina</creator><creator>Matentzoglu, Maria</creator><creator>Leutritz, Anna Linda</creator><creator>Kersken, Katharina</creator><creator>Koreny, Carolin</creator><creator>Weber, Heike</creator><creator>Kollert, Leonie</creator><creator>McNeill, Rhiannon V.</creator><creator>Reif, Andreas</creator><creator>Bahlmann, Franz</creator><creator>Trautmann-Villalba, Patricia</creator><general>Springer Vienna</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7R6</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>888</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQGEN</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>QXPDG</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3057-6150</orcidid></search><sort><creationdate>20220201</creationdate><title>A pilot study of multilevel analysis of BDNF in paternal and maternal perinatal depression</title><author>Kittel-Schneider, Sarah ; Davidova, Petra ; Kalok, Miriam ; Essel, Corina ; Ahmed, Fadia Ben ; Kingeter, Yasmina ; Matentzoglu, Maria ; Leutritz, Anna Linda ; Kersken, Katharina ; Koreny, Carolin ; Weber, Heike ; Kollert, Leonie ; McNeill, Rhiannon V. ; Reif, Andreas ; Bahlmann, Franz ; Trautmann-Villalba, Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-dbc4d37146779b030fa31fbee8d76b0b2999178dd178162fc5e79e380d1f982c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of women's mental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kittel-Schneider, Sarah</au><au>Davidova, Petra</au><au>Kalok, Miriam</au><au>Essel, Corina</au><au>Ahmed, Fadia Ben</au><au>Kingeter, Yasmina</au><au>Matentzoglu, Maria</au><au>Leutritz, Anna Linda</au><au>Kersken, Katharina</au><au>Koreny, Carolin</au><au>Weber, Heike</au><au>Kollert, Leonie</au><au>McNeill, Rhiannon V.</au><au>Reif, Andreas</au><au>Bahlmann, Franz</au><au>Trautmann-Villalba, Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pilot study of multilevel analysis of BDNF in paternal and maternal perinatal depression</atitle><jtitle>Archives of women's mental health</jtitle><stitle>Arch Womens Ment Health</stitle><addtitle>Arch Womens Ment Health</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>25</volume><issue>1</issue><spage>237</spage><epage>249</epage><pages>237-249</pages><issn>1434-1816</issn><eissn>1435-1102</eissn><abstract>Depression in the perinatal period is common in mothers worldwide. Emerging research indicates that fathers are also at risk of developing perinatal depression. However, knowledge regarding biological risk factors and pathophysiological mechanisms of perinatal depression is still scarce, particularly in fathers. It has been suggested that the neurotrophin BDNF may play a role in maternal perinatal depression; however, there is currently no data regarding paternal perinatal depression. For this pilot study, 81 expecting parents were recruited and assessed at several time points. We screened for depression using EPDS and MADRS, investigated several psychosocial variables, and took blood samples for BDNF val66met genotyping, epigenetic, and protein analysis. Between pregnancy and 12 months postpartum (pp), we found that 3.7 to 15.7% of fathers screened positive for depression, and 9.6 to 24% of mothers, with at least a twofold increased prevalence in both parents using MADRS compared with EPDS. We also identified several psychosocial factors associated with perinatal depression in both parents. The data revealed a trend that lower BDNF levels correlated with maternal depressive symptoms at 3 months pp. In the fathers, no significant correlations between BDNF and perinatal depression were found. Pregnant women demonstrated lower BDNF methylation and BDNF protein expression compared with men; however, these were found to increase postpartum. Lastly, we identified correlations between depressive symptoms and psychosocial/neurobiological factors. The data suggest that BDNF may play a role in maternal perinatal depression, but not paternal.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>34989854</pmid><doi>10.1007/s00737-021-01197-2</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-3057-6150</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of women's mental health, 2022-02, Vol.25 (1), p.237-249 |
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| subjects | Analysis Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Demographic aspects Depression - etiology Depression, Mental Depression, Postpartum - epidemiology Depression, Postpartum - psychology Diagnosis Epigenetics Fathers Fathers - psychology Female Genotyping Health aspects Humans Male Medicine Medicine & Public Health Mens health Mental depression Methylation Mothers Mothers - psychology Multilevel Analysis Original Original Article Pilot Projects Postpartum Postpartum depression Pregnancy Prenatal depression Psychiatry Psychological aspects Psychotherapy Risk Factors Womens health |
| title | A pilot study of multilevel analysis of BDNF in paternal and maternal perinatal depression |
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