Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice

Alzheimer’s disease (AD) is characterized by complex, multifactorial neuropathology, suggesting that small molecules targeting multiple neuropathological factors are likely required to successfully impact clinical progression. Acid sphingomyelinase (ASM) activation has been recognized as an importan...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-01, Vol.119 (3), p.1-12
Hauptverfasser:	Park, Min Hee, Park, Kang Ho, Choi, Byung Jo, Han, Wan Hui, Yoon, Hee Ji, Jung, Hye Yoon, Lee, Jihoon, Song, Im-Sook, Lim, Dong Yu, Choi, Min-Koo, Lee, Yang-Ha, Park, Cheol-Min, Wang, Ming, Jo, Jihoon, Kim, Hee-Jin, Kim, Seung Hyun, Schuchman, Edward H., Jin, Hee Kyung, Bae, Jae-sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Animals Autophagy Biological Sciences Brain - metabolism Disease Models, Animal Ghrelin Health services Hippocampal plasticity Hippocampus Hippocampus - metabolism Hippocampus - pathology Inflammation Memory Mice Neurodegenerative diseases Neurogenesis Neuronal Plasticity Neurons - metabolism Neuropathology Neuropathology - methods Pharmacokinetics Receptors, Ghrelin - metabolism Sphingomyelin phosphodiesterase Sphingomyelin Phosphodiesterase - genetics Sphingomyelin Phosphodiesterase - metabolism Synaptic plasticity
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