Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting Ferroptosis

Cisplatin is widely used in the treatment of solid tumors, but its application is greatly limited due to its nephrotoxicity; thus, there is still no effective medicine for the treatment of cisplatin-induced acute kidney injury (Cis-AKI). We previously identified that polydatin (PD) exerts nephroprot...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022, Vol.2022, p.9947191-14
Hauptverfasser:	Zhou, Lu, Yu, Peng, Wang, Ting-ting, Du, Yi-wei, Chen, Yang, Li, Zhen, He, Man-lin, Feng, Lan, Li, Hui-rong, Han, Xiao, Ma, Heng, Liu, Hong-bao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Animals Biotechnology Chemotherapy Cisplatin - adverse effects Creatinine Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Ferroptosis Ferroptosis - drug effects Flow cytometry Glucosides - pharmacology Glucosides - therapeutic use Humans Injuries Ischemia Kidneys Lipid peroxidation Lipids Male Medical research Mice Oxidative stress Reactive oxygen species Stilbenes - pharmacology Stilbenes - therapeutic use
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