Effects of Sambiloto (Andrographis paniculata) on GLP-1 and DPP-4 Concentrations between Normal and Prediabetic Subjects: A Crossover Study
Background. The extract of Andrographis paniculata (Burm. F.) Wall. Ex. Nees. (sambiloto) (穿心蓮 chuān xīn lián) has been reported to have an antidiabetic effect on mice models and has been used traditionally in the community. The exact mechanism of sambiloto extract in decreasing plasma glucose is un...
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| creator | Tarigan, Tri Juli Edi Purwaningsih, Erni Hernawati Yusra Abdullah, Murdani Nafrialdi Prihartono, Joedo Saraswati, Made Ratna Subekti, Imam |
| description | Background. The extract of Andrographis paniculata (Burm. F.) Wall. Ex. Nees. (sambiloto) (穿心蓮 chuān xīn lián) has been reported to have an antidiabetic effect on mice models and has been used traditionally in the community. The exact mechanism of sambiloto extract in decreasing plasma glucose is unclear, so we investigated the role of sambiloto extract in the incretin pathway in healthy and prediabetic subjects. Methods. This study was a randomized, placebo-controlled, crossover, double-blind trial. It included 38 people who were healthy and 35 people who had prediabetes. All subjects were randomly assigned to receive either the intervention sambiloto extract or a placebo. All subjects were randomly assigned to receive the first intervention for 14 days. There was a washout period between subsequent interventions. The primary outcome was glucagon-like peptide 1 (GLP-1) concentration, and secondary outcomes were fasting insulin, 2-hour postprandial insulin, homeostasis model assessment of insulin resistance (HOMA-IR), fasting blood glucose, 2-hour postprandial blood glucose, dipeptidyl peptidase-4 (DPP-4), and glycated albumin before and after the intervention. Result. After the intervention, GLP-1 concentration significantly increased in prediabetes by 19.6% compared to the placebo (p=0.043). There were no significant differences in the changes of fasting insulin, 2-hour postprandial insulin, HOMA-IR, fasting blood glucose, 2-hour postprandial blood glucose, DPP-4, and glycated albumin levels after the intervention. Sambiloto extract did not inhibit the DPP-4 enzyme in healthy and prediabetic subjects. Conclusion. Sambiloto extract increased GLP-1 concentration without inhibiting the DPP-4 enzyme in prediabetic subjects. This trial is registered with ClinicalTrials.gov (ID: NCT03455049), registered on 6 March 2018—retrospectively registered (https://clinicaltrials.gov/ct2/show/NCT03455049). |
| doi_str_mv | 10.1155/2022/1535703 |
| format | Article |
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The extract of Andrographis paniculata (Burm. F.) Wall. Ex. Nees. (sambiloto) (穿心蓮 chuān xīn lián) has been reported to have an antidiabetic effect on mice models and has been used traditionally in the community. The exact mechanism of sambiloto extract in decreasing plasma glucose is unclear, so we investigated the role of sambiloto extract in the incretin pathway in healthy and prediabetic subjects. Methods. This study was a randomized, placebo-controlled, crossover, double-blind trial. It included 38 people who were healthy and 35 people who had prediabetes. All subjects were randomly assigned to receive either the intervention sambiloto extract or a placebo. All subjects were randomly assigned to receive the first intervention for 14 days. There was a washout period between subsequent interventions. The primary outcome was glucagon-like peptide 1 (GLP-1) concentration, and secondary outcomes were fasting insulin, 2-hour postprandial insulin, homeostasis model assessment of insulin resistance (HOMA-IR), fasting blood glucose, 2-hour postprandial blood glucose, dipeptidyl peptidase-4 (DPP-4), and glycated albumin before and after the intervention. Result. After the intervention, GLP-1 concentration significantly increased in prediabetes by 19.6% compared to the placebo (p=0.043). There were no significant differences in the changes of fasting insulin, 2-hour postprandial insulin, HOMA-IR, fasting blood glucose, 2-hour postprandial blood glucose, DPP-4, and glycated albumin levels after the intervention. Sambiloto extract did not inhibit the DPP-4 enzyme in healthy and prediabetic subjects. Conclusion. Sambiloto extract increased GLP-1 concentration without inhibiting the DPP-4 enzyme in prediabetic subjects. This trial is registered with ClinicalTrials.gov (ID: NCT03455049), registered on 6 March 2018—retrospectively registered (https://clinicaltrials.gov/ct2/show/NCT03455049).</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/1535703</identifier><identifier>PMID: 35075363</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Albumin ; Andrographis paniculata ; Animal models ; Antidiabetics ; Blood glucose ; Body mass index ; Diabetes ; Diabetes mellitus ; Dipeptidyl-peptidase IV ; Enzymes ; Family medical history ; Fasting ; Flavonoids ; Glucagon ; Glucagon-like peptide 1 ; Glucose ; Homeostasis ; Hormones ; Insulin ; Insulin resistance ; Intervention ; Ligands ; Obesity ; Oral administration ; Peptidase ; Peptides ; Phytochemicals ; Placebos ; Standard deviation</subject><ispartof>Evidence-based complementary and alternative medicine, 2022, Vol.2022, p.1535703-7</ispartof><rights>Copyright © 2022 Tri Juli Edi Tarigan et al.</rights><rights>Copyright © 2022 Tri Juli Edi Tarigan et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Tri Juli Edi Tarigan et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3633-f82fe42e4f92bb7ec0afdaab2105bd1585c07b9f508e290eb92875911ce1d7283</citedby><cites>FETCH-LOGICAL-c3633-f82fe42e4f92bb7ec0afdaab2105bd1585c07b9f508e290eb92875911ce1d7283</cites><orcidid>0000-0003-1964-0561 ; 0000-0002-1740-6512 ; 0000-0001-8912-7259 ; 0000-0001-5684-9693 ; 0000-0003-3116-6575 ; 0000-0001-6086-700X ; 0000-0001-8758-3680 ; 0000-0002-4614-6617</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783715/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783715/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4009,27902,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35075363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Shang, Wen-Bin</contributor><contributor>Wen-Bin Shang</contributor><creatorcontrib>Tarigan, Tri Juli Edi</creatorcontrib><creatorcontrib>Purwaningsih, Erni Hernawati</creatorcontrib><creatorcontrib>Yusra</creatorcontrib><creatorcontrib>Abdullah, Murdani</creatorcontrib><creatorcontrib>Nafrialdi</creatorcontrib><creatorcontrib>Prihartono, Joedo</creatorcontrib><creatorcontrib>Saraswati, Made Ratna</creatorcontrib><creatorcontrib>Subekti, Imam</creatorcontrib><title>Effects of Sambiloto (Andrographis paniculata) on GLP-1 and DPP-4 Concentrations between Normal and Prediabetic Subjects: A Crossover Study</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background. The extract of Andrographis paniculata (Burm. F.) Wall. Ex. Nees. (sambiloto) (穿心蓮 chuān xīn lián) has been reported to have an antidiabetic effect on mice models and has been used traditionally in the community. The exact mechanism of sambiloto extract in decreasing plasma glucose is unclear, so we investigated the role of sambiloto extract in the incretin pathway in healthy and prediabetic subjects. Methods. This study was a randomized, placebo-controlled, crossover, double-blind trial. It included 38 people who were healthy and 35 people who had prediabetes. All subjects were randomly assigned to receive either the intervention sambiloto extract or a placebo. All subjects were randomly assigned to receive the first intervention for 14 days. There was a washout period between subsequent interventions. The primary outcome was glucagon-like peptide 1 (GLP-1) concentration, and secondary outcomes were fasting insulin, 2-hour postprandial insulin, homeostasis model assessment of insulin resistance (HOMA-IR), fasting blood glucose, 2-hour postprandial blood glucose, dipeptidyl peptidase-4 (DPP-4), and glycated albumin before and after the intervention. Result. After the intervention, GLP-1 concentration significantly increased in prediabetes by 19.6% compared to the placebo (p=0.043). There were no significant differences in the changes of fasting insulin, 2-hour postprandial insulin, HOMA-IR, fasting blood glucose, 2-hour postprandial blood glucose, DPP-4, and glycated albumin levels after the intervention. Sambiloto extract did not inhibit the DPP-4 enzyme in healthy and prediabetic subjects. Conclusion. Sambiloto extract increased GLP-1 concentration without inhibiting the DPP-4 enzyme in prediabetic subjects. This trial is registered with ClinicalTrials.gov (ID: NCT03455049), registered on 6 March 2018—retrospectively registered (https://clinicaltrials.gov/ct2/show/NCT03455049).</description><subject>Albumin</subject><subject>Andrographis paniculata</subject><subject>Animal models</subject><subject>Antidiabetics</subject><subject>Blood glucose</subject><subject>Body mass index</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Dipeptidyl-peptidase IV</subject><subject>Enzymes</subject><subject>Family medical history</subject><subject>Fasting</subject><subject>Flavonoids</subject><subject>Glucagon</subject><subject>Glucagon-like peptide 1</subject><subject>Glucose</subject><subject>Homeostasis</subject><subject>Hormones</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Intervention</subject><subject>Ligands</subject><subject>Obesity</subject><subject>Oral administration</subject><subject>Peptidase</subject><subject>Peptides</subject><subject>Phytochemicals</subject><subject>Placebos</subject><subject>Standard 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Tri Juli Edi</creator><creator>Purwaningsih, Erni Hernawati</creator><creator>Yusra</creator><creator>Abdullah, Murdani</creator><creator>Nafrialdi</creator><creator>Prihartono, Joedo</creator><creator>Saraswati, Made Ratna</creator><creator>Subekti, Imam</creator><general>Hindawi</general><general>Hindawi 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of Sambiloto (Andrographis paniculata) on GLP-1 and DPP-4 Concentrations between Normal and Prediabetic Subjects: A Crossover Study</title><author>Tarigan, Tri Juli Edi ; Purwaningsih, Erni Hernawati ; Yusra ; Abdullah, Murdani ; Nafrialdi ; Prihartono, Joedo ; Saraswati, Made Ratna ; Subekti, Imam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3633-f82fe42e4f92bb7ec0afdaab2105bd1585c07b9f508e290eb92875911ce1d7283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Albumin</topic><topic>Andrographis paniculata</topic><topic>Animal models</topic><topic>Antidiabetics</topic><topic>Blood glucose</topic><topic>Body mass index</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Dipeptidyl-peptidase IV</topic><topic>Enzymes</topic><topic>Family medical history</topic><topic>Fasting</topic><topic>Flavonoids</topic><topic>Glucagon</topic><topic>Glucagon-like peptide 1</topic><topic>Glucose</topic><topic>Homeostasis</topic><topic>Hormones</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Intervention</topic><topic>Ligands</topic><topic>Obesity</topic><topic>Oral administration</topic><topic>Peptidase</topic><topic>Peptides</topic><topic>Phytochemicals</topic><topic>Placebos</topic><topic>Standard deviation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tarigan, Tri Juli Edi</creatorcontrib><creatorcontrib>Purwaningsih, Erni Hernawati</creatorcontrib><creatorcontrib>Yusra</creatorcontrib><creatorcontrib>Abdullah, Murdani</creatorcontrib><creatorcontrib>Nafrialdi</creatorcontrib><creatorcontrib>Prihartono, Joedo</creatorcontrib><creatorcontrib>Saraswati, Made Ratna</creatorcontrib><creatorcontrib>Subekti, Imam</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open 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Study</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><spage>1535703</spage><epage>7</epage><pages>1535703-7</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. The extract of Andrographis paniculata (Burm. F.) Wall. Ex. Nees. (sambiloto) (穿心蓮 chuān xīn lián) has been reported to have an antidiabetic effect on mice models and has been used traditionally in the community. The exact mechanism of sambiloto extract in decreasing plasma glucose is unclear, so we investigated the role of sambiloto extract in the incretin pathway in healthy and prediabetic subjects. Methods. This study was a randomized, placebo-controlled, crossover, double-blind trial. It included 38 people who were healthy and 35 people who had prediabetes. All subjects were randomly assigned to receive either the intervention sambiloto extract or a placebo. All subjects were randomly assigned to receive the first intervention for 14 days. There was a washout period between subsequent interventions. The primary outcome was glucagon-like peptide 1 (GLP-1) concentration, and secondary outcomes were fasting insulin, 2-hour postprandial insulin, homeostasis model assessment of insulin resistance (HOMA-IR), fasting blood glucose, 2-hour postprandial blood glucose, dipeptidyl peptidase-4 (DPP-4), and glycated albumin before and after the intervention. Result. After the intervention, GLP-1 concentration significantly increased in prediabetes by 19.6% compared to the placebo (p=0.043). There were no significant differences in the changes of fasting insulin, 2-hour postprandial insulin, HOMA-IR, fasting blood glucose, 2-hour postprandial blood glucose, DPP-4, and glycated albumin levels after the intervention. Sambiloto extract did not inhibit the DPP-4 enzyme in healthy and prediabetic subjects. Conclusion. Sambiloto extract increased GLP-1 concentration without inhibiting the DPP-4 enzyme in prediabetic subjects. This trial is registered with ClinicalTrials.gov (ID: NCT03455049), registered on 6 March 2018—retrospectively registered (https://clinicaltrials.gov/ct2/show/NCT03455049).</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35075363</pmid><doi>10.1155/2022/1535703</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1964-0561</orcidid><orcidid>https://orcid.org/0000-0002-1740-6512</orcidid><orcidid>https://orcid.org/0000-0001-8912-7259</orcidid><orcidid>https://orcid.org/0000-0001-5684-9693</orcidid><orcidid>https://orcid.org/0000-0003-3116-6575</orcidid><orcidid>https://orcid.org/0000-0001-6086-700X</orcidid><orcidid>https://orcid.org/0000-0001-8758-3680</orcidid><orcidid>https://orcid.org/0000-0002-4614-6617</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Evidence-based complementary and alternative medicine, 2022, Vol.2022, p.1535703-7 |
| issn | 1741-427X 1741-4288 |
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| source | PubMed Central Open Access; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Albumin Andrographis paniculata Animal models Antidiabetics Blood glucose Body mass index Diabetes Diabetes mellitus Dipeptidyl-peptidase IV Enzymes Family medical history Fasting Flavonoids Glucagon Glucagon-like peptide 1 Glucose Homeostasis Hormones Insulin Insulin resistance Intervention Ligands Obesity Oral administration Peptidase Peptides Phytochemicals Placebos Standard deviation |
| title | Effects of Sambiloto (Andrographis paniculata) on GLP-1 and DPP-4 Concentrations between Normal and Prediabetic Subjects: A Crossover Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T07%3A34%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Sambiloto%20(Andrographis%20paniculata)%20on%20GLP-1%20and%20DPP-4%20Concentrations%20between%20Normal%20and%20Prediabetic%20Subjects:%20A%20Crossover%20Study&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Tarigan,%20Tri%20Juli%20Edi&rft.date=2022&rft.volume=2022&rft.spage=1535703&rft.epage=7&rft.pages=1535703-7&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2022/1535703&rft_dat=%3Cproquest_pubme%3E2622087184%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2622087184&rft_id=info:pmid/35075363&rfr_iscdi=true |