Insulin secretion and action and the response of endogenous glucose production to a lack of glucagon suppression in nondiabetic subjects

Type 2 diabetes is a disease characterized by impaired insulin secretion and defective glucagon suppression in the postprandial period. We examined the effect of impaired glucagon suppression on glucose concentrations and endogenous glucose production (EGP) at different degrees of insulin secretory...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2021-11, Vol.321 (5), p.E728-E736
Hauptverfasser:	Adams, Jon D, Egan, Aoife M, Laurenti, Marcello C, Schembri Wismayer, Daniel, Bailey, Kent R, Cobelli, Claudio, Dalla Man, Chiara, Vella, Adrian
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Glucose - drug effects Blood Glucose - metabolism Female Glucagon - antagonists & inhibitors Glucagon - metabolism Glucagon - pharmacology Glucose - metabolism Glucose Tolerance Test Healthy Volunteers Humans Insulin - pharmacology Insulin Secretion - drug effects Insulin Secretion - physiology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Male Middle Aged Postprandial Period - drug effects Postprandial Period - physiology Somatostatin - pharmacology
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