Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma

Obese asthmatics tend to have severe, poorly controlled disease and exhibit methacholine hyperresponsiveness manifesting in proximal airway narrowing and distal lung tissue collapsibility. Substantial weight loss in obese asthmatics or in mouse models of the condition decreases methacholine hyperres...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2022-02, Vol.322 (2), p.L243-L257
Hauptverfasser:	Mank, Madeleine M, Reed, Leah F, Walton, Camille J, Barup, Madison L T, Ather, Jennifer L, Poynter, Matthew E
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid - blood 3-Hydroxybutyric Acid - metabolism Animal models Animals Asthma Asthma - microbiology Asthma - physiopathology Blood levels Body weight Body weight loss Bronchial Hyperreactivity - physiopathology Diet Diet, High-Fat Diet, Ketogenic Dietary supplements Disease Models, Animal Esters - administration & dosage Gastrointestinal Microbiome Gastrointestinal surgery High fat diet Intestinal microflora Ketogenesis Ketone Bodies - metabolism Ketones Ketosis Ketosis - therapy Low carbohydrate diet Low fat diet Male Methacholine Methacholine Chloride Mice Mice, Inbred C57BL Microbiomes Nutrient deficiency Obesity - microbiology Obesity - physiopathology Weight Loss
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