Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction

The clinical relevance of IL-1β in chronic inflammation underlying atherosclerosis has been reinforced by recent evidence associating pharmacological inhibition of the cytokine with lower cardiovascular risk. Previously, we have demonstrated a direct involvement of IL-1β in endothelial senescence. T...

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Veröffentlicht in:	Aging and disease 2022-02, Vol.13 (1), p.284-297
Hauptverfasser:	Romero, Alejandra, Dongil, Pilar, Valencia, Inés, Vallejo, Susana, Hipólito-Luengo, Álvaro San, Díaz-Araya, Guillermo, Bartha, José L, González-Arlanzón, María M, Rivilla, Fernando, de la Cuesta, Fernando, Sánchez-Ferrer, Carlos F, Peiró, Concepción
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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