Advanced glycation end-products disrupt brain microvascular endothelial cell barrier: The role of mitochondria and oxidative stress

During diabetes mellitus, advanced glycation end-products (AGEs) are major contributors to the development of alterations in cerebral capillaries, leading to the disruption of the blood-brain barrier (BBB). Consequently, this is often associated with an amplified oxidative stress response in microva...

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Veröffentlicht in:	Microvascular research 2021-01, Vol.133, p.104098-104098, Article 104098
Hauptverfasser:	Dobi, Anthony, Rosanaly, Sarah, Devin, Anne, Baret, Pascal, Meilhac, Olivier, Harry, G. Jean, d'Hellencourt, Christian Lefebvre, Rondeau, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycation end-products Animals Brain - blood supply Capillary Permeability - drug effects Cell Line Diabetes Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Endothelial dysfunction Glycation End Products, Advanced - toxicity Life Sciences Mice Microvessels - drug effects Microvessels - metabolism Microvessels - pathology Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Oxidative stress Oxidative Stress - drug effects Reactive Oxygen Species - metabolism Serum Albumin, Bovine - toxicity
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