Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials
Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-relate...
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| Veröffentlicht in: | Nutrients 2022-01, Vol.14 (2), p.256 |
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| creator | Vahedian-Azimi, Amir Abbasifard, Mitra Rahimi-Bashar, Farshid Guest, Paul C Majeed, Muhammed Mohammadi, Asadollah Banach, Maciej Jamialahmadi, Tannaz Sahebkar, Amirhossein |
| description | Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-related biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant (
< 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant (
< 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds. |
| doi_str_mv | 10.3390/nu14020256 |
| format | Article |
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< 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant (
< 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu14020256</identifier><identifier>PMID: 35057437</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Clinical trials ; Coronaviruses ; COVID-19 ; COVID-19 - drug therapy ; COVID-19 vaccines ; Curcumin ; Curcumin - administration & dosage ; Curcumin - pharmacology ; Cytokine storm ; Cytokines - metabolism ; Dietary Supplements ; Disease transmission ; Female ; Hospitalization ; Humans ; Immune system ; Inflammation ; Inflammation Mediators - metabolism ; Interleukin 1 ; Interleukin 10 ; Interleukin 6 ; Interleukin-10 - metabolism ; Interleukin-1beta - metabolism ; Interleukin-6 - metabolism ; Interleukins - metabolism ; Male ; Pandemics ; Patient Acuity ; Patients ; Phytotherapy - methods ; Review ; Severe acute respiratory syndrome coronavirus 2 ; Signs and symptoms ; Systematic review ; Thromboembolism ; Transforming Growth Factor alpha - metabolism ; Treatment Outcome ; Vaccination ; Vaccines</subject><ispartof>Nutrients, 2022-01, Vol.14 (2), p.256</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-233778b28c80b2cb49e0413791c983c049ba16127dcbca68883ecaf2faa0e9433</citedby><cites>FETCH-LOGICAL-c406t-233778b28c80b2cb49e0413791c983c049ba16127dcbca68883ecaf2faa0e9433</cites><orcidid>0000-0002-8656-1444 ; 0000-0001-6690-6874</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779570/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779570/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35057437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vahedian-Azimi, Amir</creatorcontrib><creatorcontrib>Abbasifard, Mitra</creatorcontrib><creatorcontrib>Rahimi-Bashar, Farshid</creatorcontrib><creatorcontrib>Guest, Paul C</creatorcontrib><creatorcontrib>Majeed, Muhammed</creatorcontrib><creatorcontrib>Mohammadi, Asadollah</creatorcontrib><creatorcontrib>Banach, Maciej</creatorcontrib><creatorcontrib>Jamialahmadi, Tannaz</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><title>Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-related biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant (
< 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant (
< 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. 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This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-related biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant (
< 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant (
< 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35057437</pmid><doi>10.3390/nu14020256</doi><orcidid>https://orcid.org/0000-0002-8656-1444</orcidid><orcidid>https://orcid.org/0000-0001-6690-6874</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2022-01, Vol.14 (2), p.256 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Clinical trials Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 vaccines Curcumin Curcumin - administration & dosage Curcumin - pharmacology Cytokine storm Cytokines - metabolism Dietary Supplements Disease transmission Female Hospitalization Humans Immune system Inflammation Inflammation Mediators - metabolism Interleukin 1 Interleukin 10 Interleukin 6 Interleukin-10 - metabolism Interleukin-1beta - metabolism Interleukin-6 - metabolism Interleukins - metabolism Male Pandemics Patient Acuity Patients Phytotherapy - methods Review Severe acute respiratory syndrome coronavirus 2 Signs and symptoms Systematic review Thromboembolism Transforming Growth Factor alpha - metabolism Treatment Outcome Vaccination Vaccines |
| title | Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials |
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